Structure of PDB 7yz9 Chain A

Receptor sequence
>7yz9A (length=179) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence]
IIADKYDEASVLFADIVGFTERASSTAPADLVRFLDRLYSAFDELVDQHG
LEKIKVSGDSYMVVSGVPRPRPDHTQALADFALDMTNVAAQLKDPRGNPV
PLRVGLATGPVVAGVVGSRRFFYDVWGDAVNVASRMESTDSVGQIQVPDE
VYERLKDDFVLRERGVMRTWYLIGRKVAA
3D structure
PDB7yz9 Structure of Mycobacterium tuberculosis Cya, an evolutionary ancestor of the mammalian membrane adenylyl cyclases.
ChainA
Resolution1.97 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D60 I61 D104 D15 I16 D59
BS02 MN A D60 D104 D15 D59
BS03 ONM A I61 T65 R148 I16 T20 R103
Gene Ontology
Molecular Function
GO:0016849 phosphorus-oxygen lyase activity
Biological Process
GO:0009190 cyclic nucleotide biosynthetic process
GO:0035556 intracellular signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7yz9, PDBe:7yz9, PDBj:7yz9
PDBsum7yz9
PubMed35980026
UniProtP9WQ35|CYA1_MYCTU Adenylate cyclase (Gene Name=cya)

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