Structure of PDB 7yxr Chain A

Receptor sequence
>7yxrA (length=244) Species: 32644 (unidentified) [Search protein sequence]
EFPTLISLLEVIEPEVLASGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKW
AKALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDL
VINEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPK
DGLKSQAVFDEIRMTYIKELGKAIVKRSQNWQRFYQLTKLLDSMHEMVGG
LLQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFH
3D structure
PDB7yxr The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 L589 M593 Q597 E755 N759 V48 K52 L62 M66 Q70 E224 N228
BS02 DEX A M560 L563 N564 Q570 M604 F623 Q642 C736 T739 M33 L36 N37 Q43 M77 F96 Q115 C205 T208
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yxr, PDBe:7yxr, PDBj:7yxr
PDBsum7yxr
PubMed36464162
UniProtA0A1X8XLE9

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