Structure of PDB 7yxp Chain A

Receptor sequence
>7yxpA (length=241) Species: 32644 (unidentified) [Search protein sequence]
FPTLISLLEVIEPEVLYSGYDSTDTSTRLMSTLNRLGGRQVVSAVKWAKA
LPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLVIN
EERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKDGL
KSQAVFDEIRMTYIKELGKAIVKSSQNWQRFYQLTKLLDSMHEMVGGLLQ
FCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFH
3D structure
PDB7yxp The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.
ChainA
Resolution3.36 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 R585 L589 M593 Q597 M752 E755 I756 N759 V45 K49 R55 L59 M63 Q67 M218 E221 I222 N225
BS02 DEX A L563 N564 G567 Q570 M601 M604 F623 C736 T739 F749 L33 N34 G37 Q40 M71 M74 F93 C202 T205 F215
BS03 DEX A N711 W712 N177 W178
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yxp, PDBe:7yxp, PDBj:7yxp
PDBsum7yxp
PubMed36464162
UniProtA0A1X8XLE9

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