Structure of PDB 7yxn Chain A

Receptor sequence
>7yxnA (length=243) Species: 32644 (unidentified) [Search protein sequence]
GEFPTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVK
WAKALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPD
LVINEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVP
KDGLKSQAVFDEIRMTYIKELGKAIVKRNWQRFYQLTKLLDSMHEMVGGL
LQFCFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFH
3D structure
PDB7yxn The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.
ChainA
Resolution2.46 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V575 K579 L589 D590 M593 E755 N759 V49 K53 L63 D64 M67 E223 N227
BS02 DEX A M560 L563 N564 G567 Q570 M601 M604 F623 Q642 C736 T739 M34 L37 N38 G41 Q44 M75 M78 F97 Q116 C204 T207
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yxn, PDBe:7yxn, PDBj:7yxn
PDBsum7yxn
PubMed36464162
UniProtA0A1X8XLE9

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