Structure of PDB 7yxd Chain A

Receptor sequence
>7yxdA (length=241) Species: 32644 (unidentified) [Search protein sequence]
FPTLISLLEVIEPEVLYSGYDSTLPDTSTRLMSTLNRLGGRQVVSAVKWA
KALPGFRNLHLDDQMTLLQYSWMSLMAFSLGWRSYKQSNGNMLCFAPDLV
INEERMQLPYMYDQCQQMLKISSEFVRLQVSYDEYLCMKVLLLLSTVPKD
GLKSQAVFDEIRMTYIKELGKAIVKRWQRFYQLTKLLDSMHEMVGGLLQF
CFYTFVNKSLSVEFPEMLAEIISNQLPKFKAGSVKPLLFHQ
3D structure
PDB7yxd The multivalency of the glucocorticoid receptor ligand-binding domain explains its manifold physiological activities.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K579 L589 Q592 M593 Q597 M752 E755 K51 L61 Q64 M65 Q69 M217 E220
BS02 DEX A M560 L563 N564 G567 Q570 M604 Q642 T739 M32 L35 N36 G39 Q42 M76 Q114 T204
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
GO:0034056 estrogen response element binding
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:7yxd, PDBe:7yxd, PDBj:7yxd
PDBsum7yxd
PubMed36464162
UniProtA0A1X8XLE9

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