Structure of PDB 7ysy Chain A

Receptor sequence

>7ysyA (length=310) Species: 83332 (Mycobacterium tuberculosis H37Rv)

MRALVTGAAGFIGSTLVDRLLADGHSVVGLDNFATGRATNLEHLADNSAH
VFVEADIVTADLHAILEQHRPEVVFHLAAQIDVRRSVADPQFDAAVNVIG
TVRLAEAARQTGVRKIVHTSSGGSIYGTPPEYPTPETAPTDPASPYAAGK
VAGEIYLNTFRHLYGLDCSHIAPANVYGPRQDPHGEAGVVAIFAQALLSG
KPTRVFGDGTNTRDYVFVDDVVDAFVRVSADVGGGLRFNIGTGKETSDRQ
LHSAVAAAVGGPDDPEFHPPRLGDLKRSCLDIGLAERVLGWRPQIELADG
VRRTVEYFRH

3D structure

• PDB: 7ysy Crystal Structure of UDP-glucose 4-epimerase (Rv3634c) co-crystallized with UDP-N-acetylgalactosamine from Mycobacterium tuberculosis
• Chain: A
• Resolution: 2.16 Å

Enzymatic activity

• Enzyme Commision number: 5.1.3.2: UDP-glucose 4-epimerase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	G7 G10 F11 I12 D31 N32 F33 T35 G36 D56 I57 L77 A78 A79 I81 V96 T119 Y146 K150 P173 A174 N175 V176	G7 G10 F11 I12 D31 N32 F33 T35 G36 D56 I57 L77 A78 A79 I81 V96 T119 Y146 K150 P173 A174 N175 V176
BS02	UD2	A	I81 R84 S121 G123 S124 Y146 A174 N175 G188 V189 F193 R204 V205 F206 N211 R213 D248 R271	I81 R84 S121 G123 S124 Y146 A174 N175 G188 V189 F193 R204 V205 F206 N211 R213 D248 R271

Gene Ontology

Molecular Function

• GO:0003978 UDP-glucose 4-epimerase activity
• GO:0016853 isomerase activity

Biological Process

• GO:0006012 galactose metabolic process

Cellular Component

• GO:0005886 plasma membrane

External links

• PDB: RCSB:7ysy, PDBe:7ysy, PDBj:7ysy
• PDBsum: 7ysy
• UniProt: P9WN67|GALE_MYCTU UDP-glucose 4-epimerase (Gene Name=galE1)