Structure of PDB 7ysw Chain A

Receptor sequence
>7yswA (length=921) Species: 9606 (Homo sapiens) [Search protein sequence]
EPGDGAQTWARFSRPPAPEAAGLFQGTFPDGFLWAVGSAAYQTEGGWQQH
GKGASIWDTFTHHPPATGDVASDSYNNVFRDTEALRELGVTHYRFSISWA
RVLPNGSAGVPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDAY
GGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLA
PGIRGSPRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGQVSIALSSHWIN
PRRMTDHSIKECQKSLDFVLGWFAKPVFIDGDYPESMKNNLSSILPDFTE
SEKKFIKGTADFFALCFGPTLSFQLLDPHMKFRQLESPNLRQLLSWIDLE
FNHPQIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIKLDGVDVIG
YTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKMLLPKSSALFYQKLIEKN
GFPPLPENQPLEGTFPCDFAWGVVDNYIQVDTTLSQFTDLNVYLWDVHHS
KRLIKVDGVVTKKRKSYCVDFAAIQPQIALLQEMHVTHFRFSLDWALILP
LGNQSQVNHTILQYYRCMASELVRVNITPVVALWQPMAPNQGLPRLLARQ
GAWENPYTALAFAEYARLCFQELGHHVKLWITMNEPYTRNMTYSAGHNLL
KAHALAWHVYNEKFRHAQNGKISIALQADWIEPACPFSQKDKEVAERVLE
FDIGWLAEPIFGSGDYPWVMRDWLNQRNNFLLPYFTEDEKKLIQGTFDFL
ALSHYTTILVDSEKEDPIKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRK
VLNWLKFKYGDLPMYIISNGIDDGLHAEDDQLRVYYMQNYINEALKAHIL
DGINLCGYFAYSFNDRTAPRFGLYRYAADQFEPKASMKHYRKIIDSNGFP
GPETLERFCPEEFTVCTECSF
3D structure
PDB7ysw Structural basis for FGF hormone signalling.
ChainA
Resolution3.03 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 3.2.1.31: beta-glucuronidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D426 C739 D745 D815 D372 C685 D691 D761
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004566 beta-glucuronidase activity
GO:0005104 fibroblast growth factor receptor binding
GO:0005179 hormone activity
GO:0005499 vitamin D binding
GO:0008422 beta-glucosidase activity
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0017134 fibroblast growth factor binding
Biological Process
GO:0003085 negative regulation of systemic arterial blood pressure
GO:0005975 carbohydrate metabolic process
GO:0006112 energy reserve metabolic process
GO:0008340 determination of adult lifespan
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0014823 response to activity
GO:0030501 positive regulation of bone mineralization
GO:0033280 response to vitamin D
GO:0042421 norepinephrine biosynthetic process
GO:0055074 calcium ion homeostasis
GO:0071774 response to fibroblast growth factor
GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:1990776 response to angiotensin
Cellular Component
GO:0005576 extracellular region
GO:0005886 plasma membrane
GO:0016324 apical plasma membrane
GO:0070062 extracellular exosome

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7ysw, PDBe:7ysw, PDBj:7ysw
PDBsum7ysw
PubMed37286607
UniProtQ9UEF7|KLOT_HUMAN Klotho (Gene Name=KL)

[Back to BioLiP]