Structure of PDB 7ysq Chain A

Receptor sequence
>7ysqA (length=422) Species: 7227 (Drosophila melanogaster) [Search protein sequence]
MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMDSFNTFFSETGAGK
HVPRAVFVDLEPTVVDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTI
GKEIVDLVLDRIRKLADQCTGLQGFLIFHSFGGGTGSGFTSLLMERLSVD
YGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIY
DICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLV
PYPRIHFPLVTYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHG
KYMACCMLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYQPP
TVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVG
EGMEEGEFSEAREDLAALEKDY
3D structure
PDB7ysq Structural insights into the mechanism of GTP initiation of microtubule assembly.
ChainA
Resolution6.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GTP A Q11 A12 Q15 E71 A99 A100 N101 G143 G144 T145 I171 T179 N206 Y224 L227 Q11 A12 Q15 E61 A89 A90 N91 G133 G134 T135 I161 T169 N196 Y214 L217
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
GO:0032418 lysosome localization
Cellular Component
GO:0000235 astral microtubule
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005819 spindle
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ysq, PDBe:7ysq, PDBj:7ysq
PDBsum7ysq
PubMed37749104
UniProtP06603|TBA1_DROME Tubulin alpha-1 chain (Gene Name=alphaTub84B)

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