Structure of PDB 7ynz Chain A

Receptor sequence

>7ynzA (length=882) Species: 9606 (Homo sapiens)

PCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWEVGWMTSVKDWA
GVMISAQTLTGRVLVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQ
IDMAFNVFFLLYFGLRFIAANDKLWFWLEVNSVVDFFTVPPVFVSVYLNR
SWLGLRFLRALRLIQFSEILQFLNILKTSNSIKLVNLLSIFISTWLTAAG
FIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVYAKTTLGR
LFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHI
TLESVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFY
QGSVLNPHDLARVKIESADACLILANKYCADPDAEDASNIMRVISIKNYH
PKIRIITQMLQYHNKAHLLNIPSWNWKEGDDAICLAELKLGFIAQSCLAQ
GLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSNEMYTEYLSSAFVGLSFP
TVCELCFVKLKLLMISRILINPGNGTLGFFIASDAKEVKRAFFYCKKKYD
STGMFHWCAPKEIEKVILTRSEAAMTVLSGHVVVCIFGDVSSALIGLRNL
VMPLRASNFHYHELKHIVFVGSIEYLKREWETLHNFPKVSILPGTPLSRA
DLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSMQFDTTGV
NIPIITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSLM
SATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDR
CRVAQLALLDGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLST
PSQCTKRYVITNPPYEFELVPTDLIFCLMQFD

3D structure

• PDB: 7ynz Structural basis for dual allosteric gating modulation of Slo1-LRRC channel complex
• Chain: A
• Resolution: 3.5 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MG	A	E374 E399	E323 E348
BS02	CA	A	D367 R514 S533 E535 S600	D316 R463 S482 E484 S533
BS03	CA	A	Q889 D892 D895 D897	Q715 D718 D721 D723

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006813 potassium ion transport
• GO:0055085 transmembrane transport

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:7ynz, PDBe:7ynz, PDBj:7ynz
• PDBsum: 7ynz
• UniProt: Q12791|KCMA1_HUMAN Calcium-activated potassium channel subunit alpha-1 (Gene Name=KCNMA1)