Structure of PDB 7yix Chain A

Receptor sequence
>7yixA (length=482) Species: 9606 (Homo sapiens) [Search protein sequence]
LVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTV
TAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAY
LCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTT
RVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDV
IMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSH
FIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAI
QILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTS
SEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGN
GPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPM
AHLLHGVHEQNYVPHVMAYAACIGANLGHCAP
3D structure
PDB7yix The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase.
ChainA
Resolution2.96 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.3.1: alkaline phosphatase.
3.9.1.1: phosphoamidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A D60 H171 T173 D43 H154 T156
BS02 ZN A D337 H341 H454 D320 H324 H437
BS03 CA A E235 F290 E291 D306 E218 F273 E274 D289
BS04 ZN A D378 H379 D361 H362
Gene Ontology
Molecular Function
GO:0004035 alkaline phosphatase activity
GO:0004427 inorganic diphosphate phosphatase activity
GO:0005509 calcium ion binding
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0016887 ATP hydrolysis activity
GO:0033883 pyridoxal phosphatase activity
GO:0043262 ADP phosphatase activity
GO:0046872 metal ion binding
GO:0050187 phosphoamidase activity
GO:0052732 phosphoethanolamine phosphatase activity
Biological Process
GO:0001501 skeletal system development
GO:0001649 osteoblast differentiation
GO:0001958 endochondral ossification
GO:0003006 developmental process involved in reproduction
GO:0014070 response to organic cyclic compound
GO:0019725 cellular homeostasis
GO:0030282 bone mineralization
GO:0031214 biomineral tissue development
GO:0032496 response to lipopolysaccharide
GO:0032868 response to insulin
GO:0033280 response to vitamin D
GO:0034516 response to vitamin B6
GO:0036005 response to macrophage colony-stimulating factor
GO:0042822 pyridoxal phosphate metabolic process
GO:0046677 response to antibiotic
GO:0051384 response to glucocorticoid
GO:0055062 phosphate ion homeostasis
GO:0055074 calcium ion homeostasis
GO:0071407 cellular response to organic cyclic compound
GO:0071529 cementum mineralization
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0140651 futile creatine cycle
GO:0140928 inhibition of non-skeletal tissue mineralization
GO:1904383 response to sodium phosphate
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031012 extracellular matrix
GO:0031966 mitochondrial membrane
GO:0065010 extracellular membrane-bounded organelle
GO:0070062 extracellular exosome
GO:0098552 side of membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yix, PDBe:7yix, PDBj:7yix
PDBsum7yix
PubMed37422472
UniProtP05186|PPBT_HUMAN Alkaline phosphatase, tissue-nonspecific isozyme (Gene Name=ALPL)

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