Structure of PDB 7yhq Chain A

Receptor sequence

>7yhqA (length=393) Species: 3702,9606 [Search protein sequence]

KWWEEERNVFRGRADSFIARMHLVQGDRRFTPWKGSVVDSVVGVFLTQNV
SDHLSSSAFMSLASQFPVPFVRSTMDTVDWKAIRAADVKEVAETIKSRGM
NHKLAERIQGFLDRLVNDHGSIDLEWLRDVPPDKAKEYLLSFNGLGLKSV
ECVRLLTLHHLAFPVDTNVGRIAVRLGWVPLQPLPESLQLHLLEMYPMLE
SIQKYLWPRLCKLDQKTLYELHYQMITFGKVFCTKSKPNCNACPMKGECR
HFASAFSQLRTEHRVYELPDEHPLLAQLEKREPDDPCSYLLAIWVRGTIL
IPCRTAMRGSFPLNGTYFQVNEVFADHASSLNPINVPIWELPRRTVYFGT
SVPTIFKGLSTEKIQACFWKGYVCVRGFDRKTRGPKPLIARLH

3D structure

PDB

7yhq Molecular basis of the plant ROS1-mediated active DNA demethylation.

Chain

Resolution

3.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	S902 M905 H907 K908	S97 M100 H102 K103
BS02	dna	A	T606 Q607 N608 V609 S610 D611 R912 G949 L950 G951 K953 S954 D971 T972 N973 K1035 K1040	T47 Q48 N49 V50 S51 D52 R107 G144 L145 G146 K148 S149 D166 T167 N168 K230 K235
BS03	SF4	A	F1033 F1037 C1038 P1043 N1044 C1045 C1048 M1050 K1051 C1054	F228 F232 C233 P238 N239 C240 C243 M245 K246 C249

Gene Ontology

	Molecular Function
GO:0003824	catalytic activity
GO:0019104	DNA N-glycosylase activity
GO:0035514	DNA demethylase activity
GO:0051539	4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0141166	chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function

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Biological Process

External links

PDB	RCSB:7yhq, PDBe:7yhq, PDBj:7yhq
PDBsum	7yhq
PubMed	36624257
UniProt	Q05066\|SRY_HUMAN Sex-determining region Y protein (Gene Name=SRY); Q9SJQ6

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