Structure of PDB 7yg6 Chain A

Receptor sequence

>7yg6A (length=727) Species: 31330 (Ephydatia fluviatilis)

QRGSSGQPVPVSANYLPLKGNMDGVFKYAVGFNPPVEDIRSRSQLLNEHK
ELIGLTRVFDGSTLYVPKRICEQRLDLMSTRQTDGASIKVTISLVDSVKN
RDVVQLMNVIFKRILRSLKLQRIGRDYYDANSPLEVPQHKMQLWPGYVTA
INRHEGGLMLVLDVSHRVMKTDTALDFLYELYAFKQLVGSVVLTRYNNRT
YEIDDIAWDKNPRCAFQDHAGSQITFVDYYKRAYDLDITDLEQPLLIHRP
MVCLVPELCAMTGLTDAARSDFKVMKDLAVHTRVPPEKRAESFRKFIQRL
NTTKEASELLHSWGLVLDSRMLDMQGRRLPPEKILFKHSSIVANMEADWS
RECLKEHVISAVSLLDWAVLFVRKDQGKATDFVNMLSKVCPPIGMEVHEP
KMVEVVNDRTESYLRALRELIAPRLQMVVIVFPTSRDDRYSAVKKLCCIE
SPIPSQVLIARTITQQQKLRSVAQKVALQMNAKLGGELWAVEIPLKSCMV
VGIDVYHDKSYGNKSIAGFVASTNPSFTRWYSRTAMQELIHELKLCMQAA
LKKYNEMNQSLPERIIVFRDGVGEGREEYVSEFEVPQFNSCFSIFGENYC
PKLAVVVVQKRITTRIFGRSGHSYDNPPPGVIVDHTITKSYDFYLVSQHV
RQGTVSPTYYRVIYDKSGLKPDHLQRLTYKLTHMYYNWPGTIRTPAPCKY
AHKLAFLVGKSLHRDPAHELSDRLFFL

3D structure

• PDB: 7yg6 Structure basis of mammalian Piwi-piRNA silencing machinery
• Chain: A
• Resolution: 3.2 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	Y435 R438 Y440 F455 F465 Y468 C509 R539 S691 D693 Y696 K700 Q712 V713 I715 T718 K731 Q735 Q908 R911 Y945 N947 W948	Y196 R199 Y201 F216 F226 Y229 C253 R283 S435 D437 Y440 K444 Q456 V457 I459 T462 K475 Q479 Q648 R651 Y685 N687 W688
BS02	MG	A	Q735 L987	Q479 L727
BS03	MG	A	D830 K870	D570 K610

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0003723 RNA binding

External links

• PDB: RCSB:7yg6, PDBe:7yg6, PDBj:7yg6
• PDBsum: 7yg6
• PubMed: 38658622
• UniProt: D5MRY8