Structure of PDB 7yev Chain A

Receptor sequence
>7yevA (length=1128) Species: 538123 (Mammalian orthoreovirus 3) [Search protein sequence]
QKPMSTRIAEATSAIVSKHPARVGLPPTASSGHGYQCHVCSAVLFSPLDL
DAHVASHGLHGNMTLTSSEIQRHITEFISSWQNHPIVQVSADVENRKTAQ
LLHADTPRLVTWDAGLCTSFKIVPIVPAQVPQDVLAYTFFTSSYAIQSPF
PEAAVSRIVVHTRWASNVDFDRDSSVIMAPPTENNIHLFKQLLNTETLSV
RGANPLMFRANVLHMLLEFVLDNLYLNRHTGFSQDHTPFTEGANLRSLPG
PDAEKWYSIMYPTRMGTPNVSKICNFVASCVRNRVGRFDRAQMMNGAMSE
WVDVFETSDALTVSIRGRWMARLARMNINPTEIEWALTECAQGYVTVTSP
YAPSVNRLMPYRISNAERQISQIIRVMNIGNNATVIQPVLQDISVLLQRI
SPLQIDPTIISNTMSTVSESTTQTLSPASSILGKLRPSNSDFSSFRVALA
GWLYNGVVTTVIDDSSYPKDGGSVTSLENLWDFFILALALPLTTDPCAPV
KAFMTLANMMVGFETIPMDNQIYTQSRRASAFSTPHTWPRCFMNIQLISP
IDAPILRQWAEIIHRYWPNPSQIRYGTPNVFGSANLFTPPEVLLLPIDHQ
PANVTTPTLDFTNELTNWRARVCELMKNLVDNQRYQPGWTQSLVSSMRGT
LGKLKLIKSMTPMYLQQLAPVELAVIAPMLPFPPFQVPYVRLDRDRVPTM
VGVTRQSRDTITQPALSLSTTNTTVGVPLALDARAITVALLSGKYPPDLV
TNVWYADAIYPMYADTEVFSNLQRDVITCEAVQTLVTLVAQISETQYPVD
RYLDWIPSLRASAATAATFAEWVNTSMKTAFDLSDMLLEPLLSGDPRMTQ
LAIQYQQYNGRTFNVIPEMPGSVIADCVQLTAEVFNHEYNLFGIARGDII
IGRVQSTHLWSPLAPPPDLVFDRDTPGVHIFGRDCRISFGMNGAAPMIRD
ETGMMVPFEGNWIFPLALWQMNTRYFNQQFDAWIKTGELRIRIEMGAYPY
MLHYYDPRQYANAWNLTSAWLEEITPTSIPSVPFMVPISSDHDISSAPAV
QYIISTEYNDRSLFCTNSSSPQTIAGPDKHIPVERYNILTNPDAPPTQIQ
LPEVVDLYNVVTRYAYETPPITAVVMGV
3D structure
PDB7yev In situ structures of polymerase complex of mammalian reovirus illuminate RdRp activation and transcription regulation.
ChainA
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 ZN A C183 C186 H199 C37 C40 H53
Gene Ontology
Molecular Function
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006370 7-methylguanosine mRNA capping
Cellular Component
GO:0019028 viral capsid
GO:0039625 viral inner capsid

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:7yev, PDBe:7yev, PDBj:7yev
PDBsum7yev
PubMed36469786
UniProtC9E874

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