Structure of PDB 7yeh Chain A

Receptor sequence
>7yehA (length=1020) Species: 9606 (Homo sapiens) [Search protein sequence]
SFQGLMELAHREYQAGDFEAAERHCMQLWRQEPDNTGVLLLLSSIHFECR
RLDRSAHFSTLAIKQNPLLAEAYSNLGNVYKERGQLQEAIEHYRHALRLK
PDFIDGYINLAAALVAAGDMEGAVQAYVSALQYNPDLYCVRSDLGNLLKA
LGRLEEAKACYLKAIETQPNFAVAWSNLGCVFNAQGEIWLAIHHFEKAVT
LDPNFLDAYINLGNVLKEARIFDRAVAAYLRALSLSPNHAVVHGNLACVY
YEQGLIDLAIDTYRRAIELQPHFPDAYCNLANALKEKGSVAEAEDCYNTA
LRLCPTHADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLAS
VLQQQGKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYT
RAIQINPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNL
AHCLQIVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGF
RKAIAERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHP
TSHLMQSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIP
CNGKAADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTS
GALFMDYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKA
VIDFKSNGHIYDNRIVLNGIDLKAFLDSLPDVKIVKMKCPDGGDNADSSN
TALNMPVIPMNTIAEAVIEMINRGQIQITINGFSISNGLATTQINNKAAT
GEEVPRTIIVTTRSQYGLPEDAIVYCNFNQLYKIDPSTLQMWANILKRVP
NSVLWLLRFPAVGEPNIQQYAQNMGLPQNRIIFSPVAPKEEHVRRGQLAD
VCLDTPLCNGHTTGMDVLWAGTPMVTMPGETLASRVAASQLTCLGCLELI
AKNRQEYEDIAVKLGTDLEYLKKVRGKVWKQRISSPLFNTKQYTMELERL
YLQMWEHYAAGNKPDHMIKP
3D structure
PDB7yeh Cryo-EM structure of human OGT-OGA complex
ChainA
Resolution3.92 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UDP A Q849 F878 V905 A906 K908 H911 H930 T931 T932 Q830 F859 V886 A887 K889 H892 H911 T912 T913
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008289 lipid binding
GO:0008375 acetylglucosaminyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0031490 chromatin DNA binding
GO:0097363 protein O-acetylglucosaminyltransferase activity
Biological Process
GO:0000122 negative regulation of transcription by RNA polymerase II
GO:0000423 mitophagy
GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose
GO:0006110 regulation of glycolytic process
GO:0006111 regulation of gluconeogenesis
GO:0006325 chromatin organization
GO:0006357 regulation of transcription by RNA polymerase II
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007584 response to nutrient
GO:0016485 protein processing
GO:0030097 hemopoiesis
GO:0030336 negative regulation of cell migration
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031397 negative regulation of protein ubiquitination
GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032868 response to insulin
GO:0032922 circadian regulation of gene expression
GO:0035020 regulation of Rac protein signal transduction
GO:0045727 positive regulation of translation
GO:0045862 positive regulation of proteolysis
GO:0045893 positive regulation of DNA-templated transcription
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046626 regulation of insulin receptor signaling pathway
GO:0046889 positive regulation of lipid biosynthetic process
GO:0048511 rhythmic process
GO:0051963 regulation of synapse assembly
GO:0060544 regulation of necroptotic process
GO:0071333 cellular response to glucose stimulus
GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
GO:0120162 positive regulation of cold-induced thermogenesis
GO:0160076 negative regulation of non-canonical inflammasome complex assembly
GO:1902455 negative regulation of stem cell population maintenance
GO:1902459 positive regulation of stem cell population maintenance
GO:1904263 positive regulation of TORC1 signaling
Cellular Component
GO:0000123 histone acetyltransferase complex
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0017122 protein N-acetylglucosaminyltransferase complex
GO:0031966 mitochondrial membrane
GO:0032991 protein-containing complex
GO:0042995 cell projection
GO:0044545 NSL complex
GO:0045202 synapse
GO:0070822 Sin3-type complex
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7yeh, PDBe:7yeh, PDBj:7yeh
PDBsum7yeh
PubMed37907462
UniProtO15294|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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