Structure of PDB 7ydx Chain A

Receptor sequence
>7ydxA (length=271) Species: 9606 (Homo sapiens) [Search protein sequence]
NVIKMKSSDFLESAELGKVSLAFHRTQGLMIMKTVYKGPNCIEHNEALLE
EAKMMNRLRHSRVVKLLGVIIEEGKYSLVMEYMEKGNLMHVLKAEMSTPL
SVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLASF
KMWSKLNNEEHNELGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFA
NKEPYENAIAEQQLIMAIKSGNRPDVDDITEYCPREIISLMKLCWEANPE
ARPTFPGIEEKFRPFYLSQLE
3D structure
PDB7ydx Generative deep learning enables the discovery of a potent and selective RIPK1 inhibitor.
ChainA
Resolution2.642 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 3CI A I43 V76 M92 E93 M95 G98 L145 I154 A155 D156 L157 L159 F162 I31 V64 M80 E81 M83 G86 L133 I142 A143 D144 L145 L147 F150
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7ydx, PDBe:7ydx, PDBj:7ydx
PDBsum7ydx
PubMed36371441
UniProtQ13546|RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 (Gene Name=RIPK1)

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