Structure of PDB 7ybo Chain A

Receptor sequence
>7yboA (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
DLPLDPLWEFPRDRLVLGKPLGEGFGQVVRAEAFGMDPARPDQASTVAVK
MLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECA
AKGNLREFLRARRPPPDGPRSSEGPLSFPVLVSCAYQVARGMQYLESRKC
IHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAP
EALFDEVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRM
DRPPHCPPELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSE
3D structure
PDB7ybo Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2- b ]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.
ChainA
Resolution2.307 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IH7 A L473 G474 V481 R483 C552 A553 A554 G556 N557 R616 L619 L21 G22 V28 R30 C99 A100 A101 G103 N104 R158 L161
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7ybo, PDBe:7ybo, PDBj:7ybo
PDBsum7ybo
PubMed36278929
UniProtP22455|FGFR4_HUMAN Fibroblast growth factor receptor 4 (Gene Name=FGFR4)

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