Structure of PDB 7yaa Chain A

Receptor sequence
>7yaaA (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
MSQSNRELVVDFLSYKLSQKGYSWSQPMAAVKQALREAGDEFELRYRRAF
SDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESV
DKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYG
3D structure
PDB7yaa Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-xL by engaging a single-residue discrepancy
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F42 Y46 A49 E74 L75 R77 D78 N81 G83 R84 Y140 F42 Y46 A49 E74 L75 R77 D78 N81 G83 R84 Y140
BS02 JJ9 A V80 N81 W82 R84 V80 N81 W82 R84
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7yaa, PDBe:7yaa, PDBj:7yaa
PDBsum7yaa
PubMed38368459
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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