Structure of PDB 7ya5 Chain A

Receptor sequence
>7ya5A (length=139) Species: 9606 (Homo sapiens) [Search protein sequence]
GYDNREIVMKYIHYKLSQRGYEWDESEVVHLTLRQAVDDFSRRYRRDFAE
MSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNR
EMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYG
3D structure
PDB7ya5 Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-xL by engaging a single-residue discrepancy
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F104 R107 Y108 D111 F112 E136 L137 D140 G141 N143 G145 R146 A149 F40 R43 Y44 D47 F48 E72 L73 D76 G77 N79 G81 R82 A85
BS02 JFF A V142 N143 W144 W188 V78 N79 W80 W124
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7ya5, PDBe:7ya5, PDBj:7ya5
PDBsum7ya5
PubMed38368459
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2)

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