Structure of PDB 7y9x Chain A

Receptor sequence

>7y9xA (length=1458) Species: 45657 (Desulfonema ishimotonii)

MTTTMKISIEFLEPFRMTKWQESTRRNKNNKEFVRGQAFARWHRNKKDNT
KGRPYITGTLLRSAVIRSAENLLTLSDGKISEKTCCPGKFDTEDKDRLLQ
LRQRSTLRWTDKNPCPDNAETYCPFCELLGRSFRIHFGNLSLPGKPDFDG
PKAIGSQRVLNRVDFKSGKAHDFFKAYEVDHTRFPRFEGEITIDNKVSAE
ARKLLCDSLKFTDRLCGALCVIRFDNLAEKTAEQIISILDDNKKTEYTRL
LADAIRSLRRSSKLVAGLPKDHDGKDDHYLWDIGVTIRQILTTSADTKEL
KNAGKWREFCEKLGEALYLKSKDMSGGLKITRRILGDAEFHGKPDRLEKS
RSVSIGSVLKETVVCGELVAKTPFFFGAIDEDAKQTALQVLLTPDNKYRL
PRSAVRGILRRDLQTYFDSPCNAELGGRPCMCKTCRIMRGITVMDARSEY
NAPPEIRHRTRINPFTGTVAEGALFNMEVAPEGIVFPFQLRYRGSEDGLP
DALKTVLKWWAEGQAFMSGAASTGKGRFRMENAKYETLDLSDENQRNDYL
KNWGWRDEKGLEELKKRLNSGLPEPGNYRDPKWHEINVSIEMASPFINGD
PIRAAVDKRGTAVVTFVKYKAEGEEAKPVCAYKAESFRGVIRSAVARIHM
EDGVPLTELTHSDCECLLCQIFGSEYEAGKIRFEDLVFESDPEPVTFDHV
AIDRFTGGAAAKKKFDDSPLPGSPARPLMLKGSFWIRRDVLEDEEYCKAL
GKALADVNNGLYPLGGKSAIGYGQVKSLGIKGDDKRISRLMNTDVAVPEK
PKTDAEVRIEAEKVYYPHYFVEPHKKVEREEKPCGHQKFHEGRLTGKIRC
KLITKTPLIVPDTSNDDFFRYHKSYAFFRLHKQIMIPGSELRGMVSSVYE
TVTNSCFRIFDETKRLSWRMDADLQDFLPGRVTADGKHIQKFSETARVPF
YDKTQKHFDILDEQEIAGEKPVRMWVKRFRYQKAFQEIPENDPDGWECKE
GYLHVVGPSKVEFSDKKGDVINNFQGTLPSVPNDWKTIRTNDFKNRKRKN
EPVFCCEDDKGNYYTMAKYCETFFFDLKENEEYEIPEKARIKYKELLRVY
NNNPQAVPESVFQSRVARENVEKLKSGDLVYFKHNEKYVEDIVPVRISRT
VDDRMIGKRMSADLRPCHGDWVEDGDLSALNAYPEKRLLLRHPKGLCPAC
RLFGTGSYKGRVRFGFASLENDPEWLIPGKNPGDPFHGGPVMLSLLERPR
PTWSIPGSDNKFKVPGRKFYVHHHAWKTIKDGNHPTTGKAIEQSPNNRTV
EALAGGNSFSFEIAFENLKEWELGLLIHSLQLEKGLAHKLGMAKSMGFGS
VEIDVESVRLRKDWKQWRNGNSEIPNWLGKGFAKLKEWFRDELDFIENLK
KLLWFPEGDQAPRVCYPMLRKKDDPNGNSGYEELKDGEFKKEDRQKKLTT
PWTPWASS

3D structure

• PDB: 7y9x RNA-triggered protein cleavage and cell growth arrest by the type III-E CRISPR nuclease-protease.
• Chain: A
• Resolution: 2.49 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	E13 R35 Q37 A38 H43 R53 Y55 T57 G58 T59 L60 R62 S63 R67 K89 F90 D91 T92 K95 Q100 L101 R102 Q103 R104 L129 F146 H149 F150 N152 K158 R171 V172 L173 N174 R175 V176 G181 A183 D185 F186 F187 G230 H306 R375 F382 G384 G419 R444 S445 R448 G449 R452 R453 L467 G468 G469 P471 R481 T484 V485 R501 T502 R503 I504 T510 V511 L516 F517 G561 A562 A563 S564 G641 P643 K675 E677 S678 R680 G681 V682 R684 S685 S716 E719 A720 G721 D740 H741 V742 A743 I744 R746 A751 F757 G807 G808 Y863 P908 T910 S948 E949 R951 G952 S956 R967 I968 R978 R1010 R1125 S1154 K1155 A1212 K1213 Y1214 C1215 Y1245 N1248 Q1250 S1259 V1290 I1292 R1294 F1348 G1349 T1350 G1351 K1354 G1355 L1391 E1392 R1393 R1395 T1397 W1398 Y1415 G1486 M1487 A1488 K1489 Y1561 L1564 Y1576 K1580	E13 R35 Q37 A38 H43 R53 Y55 T57 G58 T59 L60 R62 S63 R67 K89 F90 D91 T92 K95 Q100 L101 R102 Q103 R104 L129 F133 H136 F137 N139 K145 R158 V159 L160 N161 R162 V163 G168 A170 D172 F173 F174 G217 H272 R333 F340 G342 G377 R402 S403 R406 G407 R410 R411 L425 G426 G427 P429 R439 T442 V443 R459 T460 R461 I462 T468 V469 L474 F475 G519 A520 A521 S522 G599 P601 K633 E635 S636 R638 G639 V640 R642 S643 S674 E677 A678 G679 D698 H699 V700 A701 I702 R704 A709 F715 G765 G766 Y816 P861 T863 S889 E890 R892 G893 S897 R908 I909 R919 R947 R980 S1009 K1010 A1067 K1068 Y1069 C1070 Y1100 N1103 Q1105 S1114 V1145 I1147 R1149 F1203 G1204 T1205 G1206 K1209 G1210 L1246 E1247 R1248 R1250 T1252 W1253 Y1270 G1341 M1342 A1343 K1344 Y1416 L1419 Y1431 K1435
BS02	ZN	A	C463 C472 C474 C477	C421 C430 C432 C435
BS03	ZN	A	H703 C706 C708 C711	H661 C664 C666 C669
BS04	ZN	A	C965 C1312 C1342 C1345	C906 C1167 C1197 C1200
BS05	ZN	A	C86 C115 C123 C126	C86 C115 C123 C126

Gene Ontology

Biological Process

• GO:0051607 defense response to virus

External links

• PDB: RCSB:7y9x, PDBe:7y9x, PDBj:7y9x
• PDBsum: 7y9x
• PubMed: 36423304
• UniProt: A0A401FT36