Structure of PDB 7y99 Chain A

Receptor sequence
>7y99A (length=140) Species: 10090 (Mus musculus) [Search protein sequence]
SQSNRELVVDFLSYKLSQKGYSWSQPMAAVKQALREAGDEFELRYRRAFS
DLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVD
KEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYG
3D structure
PDB7y99 Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-xL by engaging a single-residue discrepancy
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E41 F42 Y46 R48 A49 E74 L75 R77 D78 G83 R84 Y140 E40 F41 Y45 R47 A48 E73 L74 R76 D77 G82 R83 Y139
BS02 IQ8 A V80 N81 W82 R84 V79 N80 W81 R83
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7y99, PDBe:7y99, PDBj:7y99
PDBsum7y99
PubMed38368459
UniProtQ64373|B2CL1_MOUSE Bcl-2-like protein 1 (Gene Name=Bcl2l1)

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