Structure of PDB 7y90 Chain A

Receptor sequence
>7y90A (length=138) Species: 9606 (Homo sapiens) [Search protein sequence]
TGYDNREIVMKYIHYKLSQRGYTESEVVHLTLRQAGDDFERRYRRDFAEM
SSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNRE
MSPLVDNIALWMTEYLNRHLHTWIQDNGGWDVFVELYG
3D structure
PDB7y90 Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-xL by engaging a single-residue discrepancy
ChainA
Resolution2.09 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F104 Y108 D111 E136 L137 R139 D140 N143 G145 R146 F39 Y43 D46 E71 L72 R74 D75 N78 G80 R81
BS02 JFF A V142 N143 W144 V77 N78 W79
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7y90, PDBe:7y90, PDBj:7y90
PDBsum7y90
PubMed38368459
UniProtP10415|BCL2_HUMAN Apoptosis regulator Bcl-2 (Gene Name=BCL2)

[Back to BioLiP]