Structure of PDB 7y8n Chain A

Receptor sequence
>7y8nA (length=287) Species: 1901 (Streptomyces clavuligerus) [Search protein sequence]
PAPLTLIGLGPMGQAMGNALLDRGHGLTVWNRTASRADALVARGAVRAPT
VAAAVAANELVVLSLTDYDAMYALLGPAADALAGKVVVNLSSDTPEKTRA
GARWIAEHGGTLIAGGVTCPPSGIGSPESSAFYSGPSAAFERHRETLRTL
TRTDYRGEDPGLAALWYQIGMVMWWNAMLGYLQAVALADANGLKAADILP
HASDTVAGLPFFLRFYADRIDTGHHGGDADRLAMGTASVEHILHTMADSG
VDTALPEAVVALFRRGEAAGYAENSFSSMVELLKKPS
3D structure
PDB7y8n Engineered Imine Reductase for Larotrectinib Intermediate Manufacture
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP A G11 L12 G13 P14 M15 N34 R35 T36 R39 S67 L68 T69 L77 S95 V120 C122 Y170 G8 L9 G10 P11 M12 N31 R32 T33 R36 S64 L65 T66 L74 S92 V117 C119 Y167
BS02 4IS A T121 M174 W177 W178 T118 M171 W174 W175
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
Biological Process
GO:0016054 organic acid catabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7y8n, PDBe:7y8n, PDBj:7y8n
PDBsum7y8n
PubMed
UniProtE2PUR9

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