Structure of PDB 7y8g Chain A

Receptor sequence
>7y8gA (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
GAGSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLAD
RELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGK
LLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSI
ILLNSGVYEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLIL
SHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB7y8g Structure-guided identification of novel dual-targeting estrogen receptor alpha degraders with aromatase inhibitory activity for the treatment of endocrine-resistant breast cancer.
ChainA
Resolution2.14 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 V376 D538 E542 M543 I57 K61 V75 D227 E231 M232
BS02 IAT A M343 L346 T347 E353 L387 L391 V418 E419 M421 I424 H524 L525 S527 K531 M42 L45 T46 E52 L86 L90 V117 E118 M120 I123 H213 L214 S216 K220
External links
PDB RCSB:7y8g, PDBe:7y8g, PDBj:7y8g
PDBsum7y8g
PubMed37037140
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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