Structure of PDB 7y8d Chain A

Receptor sequence
>7y8dA (length=140) Species: 9606 (Homo sapiens) [Search protein sequence]
SQSNRELVVDFLSYKLSQKGYSWSQFMAAVKQALREAGDEFELRYRRAFS
DLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVD
KEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
3D structure
PDB7y8d Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-xL by engaging a single-residue discrepancy
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A F97 Y101 E129 L130 R132 D133 N136 G138 R139 A142 Y195 F41 Y45 E73 L74 R76 D77 N80 G82 R83 A86 Y139
BS02 JFF A N136 W137 N80 W81
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:7y8d, PDBe:7y8d, PDBj:7y8d
PDBsum7y8d
PubMed38368459
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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