Structure of PDB 7y80 Chain A

Receptor sequence
>7y80A (length=1218) Species: 237368 (Candidatus Scalindua brodae) [Search protein sequence]
MNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGKGRTAGK
SFITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSFL
RKRHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFSN
FDLDHDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGTYTGRIT
LRNEHAKKLLLASLGFVDKLCGALCRIEVIDHNDELRKQAEVIVEAFKQN
DKLEKIRILADAIRTLRLHGEGVIEKDELPDGKEERDKGHHLWDIKVQGT
ALRTKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETTEYYSSDLFIPVT
PPEGIETKEWIIVGRLKAATPFYFGVQQPSDSIPGKEEHTSFNILLDKEN
RYRIPRSALRGALRRDLRTAFGSGCNVSLGGQILCNCKVCIEMRRITLKD
SVSDFSEPPEIRYRIAKNPGTATVEDGSLFDIEVGPEGLTFPFVLRYRGH
KFPEQLSSVIRYWEENDGKNGMAWLGGLDSTGKGRFALKDIKIFEWDLNQ
KINEYIKERGMRGKEKELLEMGESSLPDGLIPYKFFEERECLFPYKENLK
PQWSEVQYTIEVGSPLLTADTISALTEPGNRDAIAYKKRVYNDGNNAIEP
EPRFAVKSETHRGIFRTAVGRRTGDLGKEDHEDCTCDMCIIFGNEHESSK
IRFEDLELINGNEFEKLEKHIDHVAIDRFTGGALDKAKFDTYPLAGSPKK
PLKLKGRFWIKKGFSGDHKLLITTALSDIRDGLYPLGSKGGVGYGWVAGI
SIDDNVINNDYVHPGHQSPKQDHKNKNIYYPHYFLDSGSKVYREKDIITH
EEFTEELLSGKINCKLETLTPLIIPDTSDENGLKLQGNKPGHKNYKFFNI
NGELMIPGSELRGMLRTHFEALTKSCFAIFGEDSTLSASKTLGGKLDKAL
HPCTGLSDGLCPGCHLFGTTDYKGRVKFGFAKYENGPEWLITRGNNPERS
LTLGVLESPRPAFSIPDDESEIPGRKFYLHHNGWRIIRQKQLEIRETVQP
ERNVTTEVMDKGNVFSFDVRFENLREWELGLLLQSLDPGKNIAHKLGKGK
PYGFGSVKIKIDSLHTFKIKRVPQSDIREYINKGYQKLIEWSGLPQWHVI
PHIDKLYKLLWVPFLSKLEPDVRYPVLNEESKGYIEGSDYTYKKLGDKDN
LPYKTRVKGLTTPWSPWN
3D structure
PDB7y80 Structural basis for the non-self RNA-activated protease activity of the type III-E CRISPR nuclease-protease Craspase
ChainA
Resolution2.71 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A E16 R19 W23 R37 Q39 A40 F41 T45 K47 K55 F57 G60 T61 L62 R64 S65 S91 F92 Q93 T94 P102 S103 F104 L105 R106 K107 R108 L133 G134 R135 A139 G140 K141 H143 Y149 H152 F153 N155 D157 I177 L178 N179 R180 V181 G186 K187 A188 D190 Y191 F192 K229 G232 E322 Y389 S391 D400 G431 R472 S473 A474 R476 G477 R481 L495 L500 T513 L514 R530 I531 A532 K533 T539 V540 S544 L545 F546 G592 G593 L594 S596 T684 A685 T687 K723 E725 T726 R728 G729 I730 R732 T733 N760 E761 S764 S765 D788 H789 V790 A791 I792 R794 G797 G798 A799 K804 F805 G853 S854 K855 Y922 P967 T969 S1001 E1002 R1004 G1005 R1008 I1021 F1420 G1421 T1422 T1423 Y1425 K1426 L1459 E1460 S1461 R1463 F1466 K1479 Y1481 L1549 G1550 K1551 G1552 K1553 P1554 Y1645 L1648 N1649 Y1663 E11 R14 W18 R32 Q34 A35 F36 T40 K42 K50 F52 G55 T56 L57 R59 S60 S86 F87 Q88 T89 P97 S98 F99 L100 R101 K102 R103 L128 G129 R130 A134 G135 K136 H138 Y144 H147 F148 N150 D152 I167 L168 N169 R170 V171 G176 K177 A178 D180 Y181 F182 K219 G222 E285 Y340 S342 D344 G375 R406 S407 A408 R410 G411 R415 L429 L434 T447 L448 R464 I465 A466 K467 T473 V474 S478 L479 F480 G526 G527 L528 S530 T618 A619 T621 K657 E659 T660 R662 G663 I664 R666 T667 N694 E695 S698 S699 D722 H723 V724 A725 I726 R728 G731 G732 A733 K738 F739 G787 S788 K789 Y830 P875 T877 S909 E910 R912 G913 R916 I929 F967 G968 T969 T970 Y972 K973 L1006 E1007 S1008 R1010 F1013 K1026 Y1028 L1096 G1097 K1098 G1099 K1100 P1101 Y1174 L1177 N1178 Y1192
BS02 ZN A C88 C121 C127 C130 C83 C116 C122 C125
BS03 ZN A C491 C501 C506 C425 C435 C440
BS04 ZN A H747 C750 C752 C755 H681 C684 C686 C689
BS05 ZN A C1018 C1406 C1414 C1417 C926 C953 C961 C964
BS06 MG A G134 D137 G129 D132
Gene Ontology
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:7y80, PDBe:7y80, PDBj:7y80
PDBsum7y80
PubMed36477448
UniProtA0A0B0EGF3

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