Structure of PDB 7y5h Chain A

Receptor sequence
>7y5hA (length=300) Species: 8364 (Xenopus tropicalis) [Search protein sequence]
KYHCHNNNKKAYDARQREQTFAKKKLCIASLICFVFISAEIVGGYILAVV
TDAAHLLVDLSSFFISLCSLWLSSKSSTTRLTFGWHRAEILGALMSVITI
WLVTGVLVYLACERLIRPDTVMLITSACALGANLVLALILHKPQTNASIR
AAFIHVIGDLFQSISVLISALIIYFKPEYKMADPICTFIFSIFVLITTVT
VLRDLLTVLMEGTPRGIHYSDVKQSILAVDGVKSVHSLHLWALTMNQVIL
SAHIATDIVGESKRILKDVTQNVFARFPFHSVTIQVEPIEDQSPECMFCY
3D structure
PDB7y5h Cryo-EM structure of a eukaryotic zinc transporter at a low pH suggests its Zn 2+ -releasing mechanism.
ChainA
Resolution3.72 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H45 H47 H3 H5
BS02 ZN A H306 H323 E357 H236 H253 E287
Gene Ontology
Molecular Function
GO:0008324 monoatomic cation transmembrane transporter activity
GO:0015297 antiporter activity
GO:0046872 metal ion binding
GO:0140826 zinc:proton antiporter activity
Biological Process
GO:0006812 monoatomic cation transport
GO:0006829 zinc ion transport
GO:0055085 transmembrane transport
GO:0062111 zinc ion import into organelle
GO:0071577 zinc ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030658 transport vesicle membrane
GO:0030667 secretory granule membrane
GO:0031410 cytoplasmic vesicle

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Cellular Component
External links
PDB RCSB:7y5h, PDBe:7y5h, PDBj:7y5h
PDBsum7y5h
PubMed36464198
UniProtQ5XHB4|ZNT8_XENTR Proton-coupled zinc antiporter SLC30A8 (Gene Name=slc30a8)

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