Structure of PDB 7y4t Chain A

Receptor sequence
>7y4tA (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
VQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSL
NRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRGSPLVVLPYMKHGD
LRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAARNCMLDE
KFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKFTTKS
DVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYE
VMLKCWHPKAEMRPSFSELVSRISAIFSTFI
3D structure
PDB7y4t Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.
ChainA
Resolution2.16 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I90 A I1084 V1092 A1108 Y1159 M1160 G1163 D1164 R1208 M1211 A1221 D1222 Y1230 I22 V30 A46 Y95 M96 G99 D100 R144 M147 A157 D158 Y166
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7y4t, PDBe:7y4t, PDBj:7y4t
PDBsum7y4t
PubMed36355693
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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