Structure of PDB 7y4i Chain A

Receptor sequence
>7y4iA (length=822) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]
FSNGSRSSSSSAGVLSPSNDTLSYANILRARNKFADALALYEAMLEKDSK
NVEAHIGKGICLQTQNKGNLAFDCFSEAIRLDPHNACALTHCGILHKEEG
RLVEAAESYQKALMADASYKPAAECLAIVLTDLGTSLKLAGNTQEGIQKY
YEALKIDPHYAPAYYNLGVVYSEMMQYDNALSCYEKAALERPMYAEAYCN
MGVIYKNRGDLEMAITCYERCLAVSPNFEIAKNNMAIALTDLGTKVKLEG
DVTQGVAYYKKALYYNWHYADAMYNLGVAYGEMLKFDMAIVFYELAFHFN
PHCAEACNNLGVLYKDRDNLDKAVECYQMALSIKPNFAQSLNNLGVVYTV
QGKMDAAASMIEKAILANPTYAEAFNNLGVLYRDAGNITMAIDAYEECLK
IDPDSRNAGQNRLLAMNYINEGLDDKLFEAHRDWGWRFTRLHPQYTSWDN
LKDPERPITIGYISPDFFTHSVSYFIEAPLTHHDYTKYKVVVYSAVVKAD
AKTYRFRDKVLKKGGVWKDIYGIDEKKIASMVREDKIDILVELTGHTANN
KLGTMACRPAPVQVTWIGYPNTTGLPTVDYRITDSLADPPDTKQKQVEEL
VRLPDCFLCYTPSPEAGPVSPTPALSNGFVTFGSFNNLAKITPKVLQVWA
RILCAVPNSRLVVKCKPFCCDSIRQRFLTTLEQLGLESKRVDLLPLILFN
HDHMQAYSLMDISLDTFPYAGTTTTCESLYMGVPCVTMAGSVHAHNVGVS
LLTKVGLGHLVAKNEDEYVQLSVDLASDVTALSKLRMSLRDLMAGSPVCN
GPSFAVGLESAYRNMWKKYCKG
3D structure
PDB7y4i Structural insights into mechanism and specificity of the plant protein O-fucosyltransferase SPINDLY.
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.221: peptide-O-fucosyltransferase.
2.4.1.255: protein O-GlcNAc transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GDP A S496 Y499 K665 L721 I722 L723 H728 G746 T747 T748 T749 E752 S471 Y474 K640 L696 I697 L698 H703 G721 T722 T723 T724 E727
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0016262 protein N-acetylglucosaminyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046922 peptide-O-fucosyltransferase activity
GO:0097363 protein O-acetylglucosaminyltransferase activity
Biological Process
GO:0006486 protein glycosylation
GO:0009736 cytokinin-activated signaling pathway
GO:0009740 gibberellic acid mediated signaling pathway
GO:0009908 flower development
GO:0009938 negative regulation of gibberellic acid mediated signaling pathway
GO:0030154 cell differentiation
GO:0036066 protein O-linked fucosylation
GO:0048511 rhythmic process
GO:2000377 regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7y4i, PDBe:7y4i, PDBj:7y4i
PDBsum7y4i
PubMed36456586
UniProtQ96301|SPY_ARATH Probable UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase SPINDLY (Gene Name=SPY)

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