Structure of PDB 7xzu Chain A

Receptor sequence
>7xzuA (length=259) Species: 3988 (Ricinus communis) [Search protein sequence]
QYPIINFTTAGATVQSYTNFIRAVRGRLTTGADVRHEIPVLPNRVGLPIN
QRFILVELSNHAELSVTLALDVTNAYVVGYRAGNSAYFFHPDNQEDAEAI
THLFTDVQNRYTFAFGGNYDRLEQLAGNLRENIELGNGPLEEAISALYYY
STGGTQLPTLARSFIICIQMISEAARFQYIEGEMRTRIRYNRRSAPDPSV
ITLENSWGRLSTAIQESNQGAFASPIQLQRRNGSKFSVYDVSILIPIIAL
MVYRCAPPP
3D structure
PDB7xzu Conformational change in ricin toxin A-Chain: A critical factor for inhibitor binding to the secondary pocket.
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.2.22: rRNA N-glycosylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IEK A Y80 V81 G121 N122 Y123 I172 R180 Y76 V77 G117 N118 Y119 I168 R176
BS02 IEK A D75 N78 Y80 D96 D100 W211 R258 D71 N74 Y76 D92 D96 W207 R254
Gene Ontology
Molecular Function
GO:0030598 rRNA N-glycosylase activity
Biological Process
GO:0017148 negative regulation of translation

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Molecular Function
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Biological Process
External links
PDB RCSB:7xzu, PDBe:7xzu, PDBj:7xzu
PDBsum7xzu
PubMed35998389
UniProtP02879|RICI_RICCO Ricin

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