Structure of PDB 7xzp Chain A

Receptor sequence
>7xzpA (length=557) Species: 1261 (Peptostreptococcus anaerobius) [Search protein sequence]
EFKTDIEIAQEANPQDIRDIAKKINLSEDDIELYGKYKAKIDYNVLNRTK
SRAGKLILTTAINPTPAGEGKTTTSIGVADALAKLGKNVIAALREPSMGP
VFGIKGGAAGGGYAQVVPMEDINLHFTGDMHAIGAANNLLAAMLDNHVYQ
TNSLNINPKRITWRRCVDMNDRQLRNVVDGLGKKVDGVTREDGFDITVAS
EVMAAFCLSNNISELKENLGNIVVAYNYSGKPVTARDLNAHGAMAAILKD
ALKPNLVQTLEGTPAILHGGPFANIAHGCNSIIATKMGMHMADYVVTEAG
FGADLGAEKFLDIKCRKAGIRPDAVIIVATVRALKYNGGVAKDQLNNENL
EALEKGLPNLLKHIENITQVYKIPAVVAINRFPLDTDAELALVRSKCEEL
GVKVALSEVWANGGEGGIEVANEVLKLIEEGENNFEYCYEEDMTIKEKLN
AIATKIYGADGVNYTKEANKQIAELEELGFGNLPVCVAKTQYSLSDDQTK
LGRPTGFTIEVRQANISAGAGFVVVMTGEIMKMPGLPKLPAAERIDVDEN
GKISGLF
3D structure
PDB7xzp Berberine targets FtfL to suppress intestinal bacteria that promote colorectal carcinogenesis
ChainA
Resolution2.56 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.3.4.3: formate--tetrahydrofolate ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 BER A V149 Q151 T152 N153 P159 Y229 V148 Q150 T151 N152 P158 Y228
BS02 PRO A R237 H242 R236 H241
BS03 PRO A K184 K185 K183 K184
BS04 PRO A Q11 P119 M120 E121 Q10 P118 M119 E120
BS05 PRO A R173 R176 R172 R175
BS06 PRO A Y150 Q151 Y149 Q150
Gene Ontology
Molecular Function
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
Biological Process
GO:0006730 one-carbon metabolic process
GO:0035999 tetrahydrofolate interconversion

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Molecular Function
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Biological Process
External links
PDB RCSB:7xzp, PDBe:7xzp, PDBj:7xzp
PDBsum7xzp
PubMed38049785
UniProtA0A379CIH2

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