Structure of PDB 7xzh Chain A

Receptor sequence
>7xzhA (length=729) Species: 9606 (Homo sapiens) [Search protein sequence]
MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQD
KMICLPCKWVTKDSCNDSTGPTGIKYDLDRHQYNYVDAVCYENRLHWFAK
YFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFVSILLKCFDSPWTTRAL
SEVLDKKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFILI
ICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHPLATLFKILASFYISL
VIFYGLICMYTLWWMLRRSLKKYSFESIREESSYSDIPDVKNDFAFMLHL
IDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQDKL
ELHLFMLSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYH
TAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLS
AENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEG
TKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKT
IEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIP
TQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELF
QCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPL
LKRSGLVVEEDLFNTLPPEVKERLWRADK
3D structure
PDB7xzh cryo-EM structure of human LRRC8A
ChainA
Resolution2.78 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 P5S A A138 F142 F146 R148 R262 R266 A115 F119 F123 R125 R184 R188
BS02 CLR A I320 S323 F324 S327 I242 S245 F246 S249
BS03 CLR A K319 S323 I326 S327 F331 K241 S245 I248 S249 F253
BS04 P5S A W23 F27 Y30 W23 F27 Y30
Gene Ontology
Molecular Function
GO:0005225 volume-sensitive anion channel activity
GO:0005253 monoatomic anion channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0140360 cyclic-GMP-AMP transmembrane transporter activity
Biological Process
GO:0001678 intracellular glucose homeostasis
GO:0002329 pre-B cell differentiation
GO:0006820 monoatomic anion transport
GO:0006884 cell volume homeostasis
GO:0006970 response to osmotic stress
GO:0007283 spermatogenesis
GO:0015734 taurine transmembrane transport
GO:0015810 aspartate transmembrane transport
GO:0030154 cell differentiation
GO:0032024 positive regulation of insulin secretion
GO:0034214 protein hexamerization
GO:0034220 monoatomic ion transmembrane transport
GO:0045663 positive regulation of myoblast differentiation
GO:0055085 transmembrane transport
GO:0098656 monoatomic anion transmembrane transport
GO:0140361 cyclic-GMP-AMP transmembrane import across plasma membrane
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0034702 monoatomic ion channel complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xzh, PDBe:7xzh, PDBj:7xzh
PDBsum7xzh
PubMed
UniProtQ8IWT6|LRC8A_HUMAN Volume-regulated anion channel subunit LRRC8A (Gene Name=LRRC8A)

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