Structure of PDB 7xyk Chain A

Receptor sequence
>7xykA (length=290) Species: 654913 (Shrimp white spot syndrome virus (isolate Tongan)) [Search protein sequence]
AMEGEHQYLNLVREILERGVKKDDRTGTGTLSIFGPQMRFSLRDDTIPVL
TTKKIFWRGVVEELLWFIRGNTDAKELAKKKIHIWNANGSREFLDSRGLY
DRAEGDLGPVYGFQWRHFGAEYDTCSSDYTGKGIDQLANILKTLRENPDD
RRMIMTAWNPMDLHLMALPPCHMTAQFYVANGELSCQLYQRSGDVGLGVP
FNIASYSLLTHLMASMVGLKPGEFILTLGDAHIYNTHIEVLKKQLCRVPR
PFPKLRILMAPEKIEDFTIDMFYLEGYQPHSGNLQMKMAV
3D structure
PDB7xyk Structure of WSSV thymidylate synthase in complex with dUMP and raltitrexed
ChainA
Resolution1.433 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.1.1.45: thymidylate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 UMP A R24 C170 R190 S191 D193 N201 H231 Y233 R25 C171 R191 S192 D194 N202 H232 Y234
BS02 D16 A I83 W84 D193 L196 G197 F200 M285 M287 I84 W85 D194 L197 G198 F201 M286 M288
BS03 UMP A R150 R151 R151 R152
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016741 transferase activity, transferring one-carbon groups
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7xyk, PDBe:7xyk, PDBj:7xyk
PDBsum7xyk
PubMed
UniProtQ77J90

[Back to BioLiP]