Structure of PDB 7xuh Chain A

Receptor sequence
>7xuhA (length=707) Species: 9606 (Homo sapiens) [Search protein sequence]
QYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSL
FPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLY
ASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNNSSL
LDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAA
VHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALIV
LLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVV
GDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYP
LDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGA
IIVLIVVLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYD
CLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTN
IYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRIL
RKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQ
PINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLK
SILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVL
HILMKKD
3D structure
PDB7xuh structure of human SLC26A3 in complex with TQR1122
ChainA
Resolution2.76 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 I2L A P131 I132 L205 I210 F213 V353 S356 S398 M451 P124 I125 L187 I192 F195 V335 S338 S380 M433
BS02 Y01 A V241 K245 V223 K227
BS03 Y01 A F244 Y248 F226 Y230
BS04 Y01 A F336 Q337 F318 Q319
Gene Ontology
Molecular Function
GO:0005452 solute:inorganic anion antiporter activity
GO:0005515 protein binding
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
GO:0015297 antiporter activity
GO:0019531 oxalate transmembrane transporter activity
GO:0140900 chloride:bicarbonate antiporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0006820 monoatomic anion transport
GO:0015701 bicarbonate transport
GO:0019532 oxalate transport
GO:0048240 sperm capacitation
GO:0051454 intracellular pH elevation
GO:0055085 transmembrane transport
GO:0060081 membrane hyperpolarization
GO:0071320 cellular response to cAMP
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0097225 sperm midpiece

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xuh, PDBe:7xuh, PDBj:7xuh
PDBsum7xuh
PubMed
UniProtP40879|S26A3_HUMAN Chloride anion exchanger (Gene Name=SLC26A3)

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