Structure of PDB 7xuc Chain A

Receptor sequence

>7xucA (length=272) Species: 9606 (Homo sapiens)

IRTEKIICRDVARGYENVPIPCVNGVDGEPCPEDYKYISENCETSTMNID
RNITHLQHCTCVDDCSSSNCLCGQLSIRCWYDKDGRLLQEFNKPPLIFEC
NQACSCWRNCKNRVVQSGIKVRLQLYRTAKMGWGVRALQTIPQGTFICEY
VGELISDAEADVREDDSYLFDLDNKDGEVYCIDARYYGNISRFINHLCDP
NIIPVRVFMLHQDLRFPRIAFFSSRDIRTGEELGFDYGDRFWDIKSKYFT
CQCGSEKCKHSAEAIALEQSRL

3D structure

• PDB: 7xuc Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.
• Chain: A
• Resolution: 1.67 Å

Enzymatic activity

• Enzyme Commision number: 2.1.1.-
  2.1.1.367: [histone H3]-lysine(9) N-methyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	A	C974 C987 C1017 C1021	C59 C72 C100 C104
BS02	ZN	A	C980 C1017 C1023 C1027	C65 C100 C106 C110
BS03	ZN	A	C974 C976 C980 C985	C59 C61 C65 C70
BS04	ZN	A	C1115 C1168 C1170 C1175	C198 C251 C253 C258
BS05	SFG	A	M1048 W1050 S1084 Y1085 R1109 F1110 N1112 H1113 Y1154 F1166 C1168	M131 W133 S167 Y168 R192 F193 N195 H196 Y237 F249 C251
BS06	I6S	A	D1083 L1086 F1087 D1088 R1123 F1152 Y1154 R1157 F1158 I1161	D166 L169 F170 D171 R206 F235 Y237 R240 F241 I244

Gene Ontology

Molecular Function

• GO:0002039 p53 binding
• GO:0008270 zinc ion binding
• GO:0016279 protein-lysine N-methyltransferase activity
• GO:0042054 histone methyltransferase activity

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:7xuc, PDBe:7xuc, PDBj:7xuc
• PDBsum: 7xuc
• PubMed: 36882960
• UniProt: Q96KQ7|EHMT2_HUMAN Histone-lysine N-methyltransferase EHMT2 (Gene Name=EHMT2)