Structure of PDB 7xso Chain A

Receptor sequence

>7xsoA (length=1271) Species: 237368 (Candidatus Scalindua brodae)

DMNITVELTFFEPYRLVEWFDWDARKKSHSAMRGQAFAQWTWKGKGRTAG
KSFITGTLVRSAVIKAVEELLSLNNGKWEGVPCCNGSFQTDESKGKKPSF
LRKRHTLQWQANNKNICDKEEACPFCILLGRFDNAGKVHERNKDYDIHFS
NFDLDHKQEKNDLRLVDIASGRILNRVDFDTGKAKDYFRTWEADYETYGT
YTGRITLRNEHAKKLLLASLGFVDKLCGALCRIEVIKSEDHNDELRKQAE
VIVEAFKQNDKLEKIRILADAIRTLRLHGEGVIEKDELPDGKEERDKGHH
LWDIKVQGTALRTKLKELWQSNKDIGWRKFTEMLGSNLYLIYKKETGTEY
YSKAHDSEGSDLFIPVTPPEGIETKEWIIVGRLKAATPFYFGVQQPSDSI
PGKEKNEHTSFNILLDKENRYRIPRSALRGALRRDLRTAFGSGCNVSLGG
QILCNCKVCIEMRRITLKDSVSDFSEPPEIRYRIAKNPGTATVEDGSLFD
IEVGPEGLTFPFVLRYRGHKFPEQLSSVIRYWEENDGKNGMAWLGGLDST
GKGRFALKDIKIFEWDLNQKINEYIKERGMRGKEKELLEMGESSLPDGLI
PYKFFEERECLFPYKENLKPQWSEVQYTIEVGSPLLTADTISALTEPGNR
DAIAYKKRVYNDGNNAIEPEPRFAVKSETHRGIFRTAVGRRTGDLGKEDH
EDCTCDMCIIFGNEHESSKIRFEDLELINGNEFEKLEKHIDHVAIDRFTG
GALDKAKFDTYPLAGSPKKPLKLKGRFWIKKGFSGDHKLLITTALSDIRD
GLYPLGSKGGVGYGWVAGISIDDNVPDDFKEMINPINNDYVHPGHQSPKQ
DHKNKNIYYPHYFLDSGSKVYREKDIITHEEFTEELLSGKINCKLETLTP
LIIPDTSDENGLKLQGNKPGHKNYKFFNINGELMIPGSELRGMLRTHFEA
LTKSCFAIFGEDSTLSWKCASKTLGGKLDKALHPCTGLSDGLCPGCHLFG
TTDYKGRVKFGFAKYENGPEWLITRGNNPERSLTLGVLESPRPAFSIPDD
ESEIPGRKFYLHHNGWRIIRQKQLEIRETVQPERNVTTEVMDKGNVFSFD
VRFENLREWELGLLLQSLDPGKNIAHKLGKGKPYGFGSVKIKIDSLHTFK
INSNNDKIKRVPQSDIREYINKGYQKLIEWSGNNSIQKGNVLPQWHVIPH
IDKLYKLLWVPFLNDSKLEPDVRYPVLNEESKGYIEGSDYTYKKLGDKDN
LPYKTRVKGLTTPWSPWNPFQ

3D structure

• PDB: 7xso Target RNA activates the protease activity of Craspase to confer antiviral defense.
• Chain: A
• Resolution: 3.01 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	E16 R19 R37 F41 T45 T61 L62 R64 S91 F92 Q93 T94 K101 P102 S103 F104 L105 R106 R108 G134 K141 H143 Y149 H152 F153 N155 D157 I177 L178 N179 V181 G186 A188 D190 F192 K229 Y389 S391 D400 R472 S473 R476 R481 S494 L495 L500 R510 T513 L514 R530 I531 A532 V540 L545 F546 G593 A685 R728 G729 I730 R732 N760 E761 S765 H789 V790 I792 R794 A799 K804 F805 S854 P967 T969 S1001 E1002 R1004 R1008 T1422 T1423 L1459 E1460 P1462 R1463 Y1481 G1552 K1553 P1554 Y1645 Y1663	E12 R15 R33 F37 T41 T57 L58 R60 S87 F88 Q89 T90 K97 P98 S99 F100 L101 R102 R104 G130 K137 H139 Y145 H148 F149 N151 D153 I173 L174 N175 V177 G182 A184 D186 F188 K225 Y350 S352 D361 R425 S426 R429 R434 S447 L448 L453 R463 T466 L467 R483 I484 A485 V493 L498 F499 G546 A638 R681 G682 I683 R685 N713 E714 S718 H742 V743 I745 R747 A752 K757 F758 S807 P904 T906 S938 E939 R941 R945 T1001 T1002 L1038 E1039 P1041 R1042 Y1060 G1131 K1132 P1133 Y1224 Y1242
BS02	ZN	A	C88 C127 C130	C84 C123 C126
BS03	ZN	A	C491 C501 C503 C506	C444 C454 C456 C459
BS04	ZN	A	H747 C750 C752 C755	H700 C703 C705 C708
BS05	ZN	A	C1414 C1417	C993 C996

Gene Ontology

Molecular Function

• GO:0003723 RNA binding

Biological Process

• GO:0051607 defense response to virus

External links

• PDB: RCSB:7xso, PDBe:7xso, PDBj:7xso
• PDBsum: 7xso
• PubMed: 36306795
• UniProt: A0A0B0EGF3