Structure of PDB 7xs6 Chain A

Receptor sequence

>7xs6A (length=729) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]

FKLWNGNFVFDSPISKTLLDQYATTTENANTLPNEFKFMRYQAVTCEPNQ
LAEKNFTVRQLKYLTPRETELMLVVTMYNEDHILLGRTLKGIMDNVKYMV
KKKNSSTWGPDAWKKIVVCIISDGRSKINERSLALLSSLGCYQDGFAKDE
INEKKVAMHVYEHTTMINITNISESEVSLECNQGTVPIQLLFCLKEQNQK
KINSHRWAFEGFAELLRPNIVTLLDAGTMPGKDSIYQLWREFRNPNVGGA
CGEIRTDLGKRFVKLLNPLVASQNFEYKMSNILDKTTESNFGFITVLPGA
FSAYRFEAVRGQPLQKYFYGEGFHFFSSNMYLAEDRILCFEVVTKKNCNW
ILKYCRSSYASTDVPERVPEFILQRRRWLNGSFFASVYSFCHFYRVWSSG
HNIGRKLLLTVEFFYLFFNTLISWFSLSSFFLVFRILTVSIALAYHSAFN
VLSVIFLWLYGICTLSTFILSLGNKPKSTEKFYVLTCVIFAVMMIYMIFC
SIFMSVKSFQNILKTEAFRDIVISLGSTYCLYLISSIIYLQPWHMLTSFI
QYILLSPSYINVLNIYAFCNVHDLSWGTKGAMANPLGKINTTEDGTFKME
VLVSSSEIQANYDKYLKVLNDFDPKSESRPTEPSYDEKKTGYYANVRSLV
IIFWVITNFIIVAVVLETGGIADYIAMKSISTAEIPLMTSKASIYFNVIL
WLVALSALIRFIGCSIYMIVRFFKKVTFR

3D structure

PDB

7xs6 structure of a membrane-integrated glycosyltransferase with inhibitor

Chain

Resolution

2.9 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.4.1.16: chitin synthase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	0V9	A	F1052 T1061 G1062 D1066	F659 T668 G669 D673
BS02	0V9	A	F813 L839 W840 G843 L847 F850 V1048 L1059 T1061	F431 L457 W458 G461 L465 F468 V655 L666 T668
BS03	BGI	A	T453 M454 Y455 E457 D500 K578 D602 P675 A677 T744 D745 Q756 W760	T76 M77 Y78 E80 D123 K201 D225 P298 A300 T362 D363 Q374 W378

Gene Ontology

	Molecular Function
GO:0004100	chitin synthase activity
GO:0016757	glycosyltransferase activity
GO:0016758	hexosyltransferase activity

	Biological Process
GO:0000920	septum digestion after cytokinesis
GO:0006031	chitin biosynthetic process
GO:0071555	cell wall organization

	Cellular Component
GO:0005886	plasma membrane
GO:0030428	cell septum
GO:0045009	chitosome
GO:0071944	cell periphery

View graph for
Molecular Function

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Biological Process

View graph for
Cellular Component

External links

PDB	RCSB:7xs6, PDBe:7xs6, PDBj:7xs6
PDBsum	7xs6
PubMed
UniProt	P08004\|CHS1_YEAST Chitin synthase 1 (Gene Name=CHS1)

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