Structure of PDB 7xmd Chain A

Receptor sequence

>7xmdA (length=657) Species: 562 (Escherichia coli) [Search protein sequence]

KLSLDAVPFHEPIVMVTIAGIILGGLALVGLITYFGKWTYLWKEWLTSVD
HKRLGIMYIIVAIVMLLRGFADAIMMRSQQALASAGEAGFLPPHHYDQIF
TAHGVIMIFFVAMPFVIGLMNLVVPLQIGARDVAFPFLNNLSFWFTVVGV
ILVNVSLGVGEFAQTGWLAYPPLSGIEYSPGVGVDYWIWSLQLSGIGTTL
TGINFFVTILKMRAPGMTMFKMPVFTWASLCANVLIIASFPILTVTVALL
TLDRYLGTHFFTNDMGGNMMMYINLIWAWGHPEVYILILPVFGVFSEIAA
TFSRKRLFGYTSLVWATVCITVLSFIVWLHHFFTMGAGANVNAFFGITTM
IIAIPTGVKIFNWLFTMYQGRIVFHSAMLWTIGFIVTFSVGGMTGVLLAV
PGADFVLHNSLFLIAHFHNVIIGGVVFGCFAGMTYWWPKAFGFKLNETWG
KRAFWFWIIGFFVAFMPLYALGFMGMTRRLSQQIDPQFHTMLMIAASGAV
LIALGILCLVIQMYVSIRDRDQNRDLTGDPWGGRTLEWATSSPPPFYNFA
VVPHVHERDAFWEMKEKGEAYKKPDHYEEIHMPKNSGAGIVIAAFSTIFG
FAMIWHIWWLAIVGFAGMIITWIVKSFDEDVDYYVPVAEIEKLENQHFDE
ITKAGLK

3D structure

PDB

7xmd Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases.

Chain

Resolution

2.99 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

7.1.1.3: ubiquinol oxidase (H(+)-transporting).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEO	A	W170 W280 V287 I291 H333 H334 A356 T359 G360 G395 G398 V399 L401 A402 D407 H411 L416 H419 F420 V423 I424 R481	W167 W277 V284 I288 H330 H331 A353 T356 G357 G392 G395 V396 L398 A399 D404 H408 L413 H416 F417 V420 I421 R478
BS02	HEM	A	F73 A76 M79 R80 Q83 F103 H106 G107 M110 I111 G169 W170 I417 F420 H421 I424 I425 W460 R481 R482 I505	F70 A73 M76 R77 Q80 F100 H103 G104 M107 I108 G166 W167 I414 F417 H418 I421 I422 W457 R478 R479 I502
BS03	CU	A	H284 H333 H334	H281 H330 H331
BS04	JYR	A	M18 I21 R71 A74 D75 M78 Q101 I102 L160	M15 I18 R68 A71 D72 M75 Q98 I99 L157

Gene Ontology

	Molecular Function
GO:0004129	cytochrome-c oxidase activity
GO:0005507	copper ion binding
GO:0005515	protein binding
GO:0009055	electron transfer activity
GO:0009486	cytochrome bo3 ubiquinol oxidase activity
GO:0015078	proton transmembrane transporter activity
GO:0015453	oxidoreduction-driven active transmembrane transporter activity
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0048039	ubiquinone binding

	Biological Process
GO:0009060	aerobic respiration
GO:0015990	electron transport coupled proton transport
GO:0019646	aerobic electron transport chain
GO:0022904	respiratory electron transport chain
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005886	plasma membrane
GO:0009319	cytochrome o ubiquinol oxidase complex
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7xmd, PDBe:7xmd, PDBj:7xmd
PDBsum	7xmd
PubMed	36481732
UniProt	P0ABI8\|CYOB_ECOLI Cytochrome bo(3) ubiquinol oxidase subunit 1 (Gene Name=cyoB)

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