Structure of PDB 7xm5 Chain A

Receptor sequence
>7xm5A (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
VGRLIYTAGGYFRQSLSYLEAYNPSDGTWLRLADLQVPRSGLAGCVVGGL
LYAVGGRNNTDSSALDCYNPMTNQWSPCAPMSVPRNRIGVGVIDGHIYAV
GGSHGCIHHNSVERYEPERDEWHLVAPMLTRRIGVGVAVLNRLLYAVGGF
DGTNRLNSAECYYPERNEWRMITAMNTIRSGAGVCVLHNCIYAAGGYDGQ
DQLNSVERYDVETETWTFVAPMKHRRSALGITVHQGRIYVLGGYDGHTFL
DSVECYDPDTDTWSEVTRMTSGRSGVGVAVT
3D structure
PDB7xm5 Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GCI A Y334 R336 R380 N414 R415 R483 S508 Y525 S555 A556 F577 S602 Y11 R13 R57 N86 R87 R155 S180 Y197 S227 A228 F249 S274
External links
PDB RCSB:7xm5, PDBe:7xm5, PDBj:7xm5
PDBsum7xm5
PubMed
UniProtQ14145|KEAP1_HUMAN Kelch-like ECH-associated protein 1 (Gene Name=KEAP1)

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