Structure of PDB 7xlq Chain A

Receptor sequence

>7xlqA (length=1319) Species: 9606 (Homo sapiens)

NIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLE
KTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILAT
AGTHFNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIG
LLLFFAILMFAIIGLEFYSGKLHRACFMNNSGILEGFDPPHPCGVQGCPA
GYECKDWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGAT
WNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQ
IERELNGYRAWIDKAHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVA
IVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFD
FGVTVGSIFEVVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVV
SLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFNFNDGTPSANFDTFP
AAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTL
LNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALRHHMSVWEQRTSQLR
KHRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDY
VFTGVFTFEMVIKMIDQGLWNILDFVVVVGALVAFALANALGTNKGRDIK
TIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFI
FAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKGREWKRHE
FHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIF
YVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAIS
AKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSA
PCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITVIG
SITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQ
SFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGS
LMLLFRSATGEAWQEIMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVY
FVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRVWAEYD
RAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPVAEDMT
VHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLD
LLVPMPKASDLTVGKIYAA

3D structure

• PDB: 7xlq Molecular insights into the gating mechanisms of voltage-gated calcium channel Ca V 2.3.
• Chain: A
• Resolution: 3.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	Y01	A	V1494 M1497 T1505 Y1506 L1513	V942 M945 T953 Y954 L961
BS02	Y01	A	T564 F1299 F1303 R1396 E1398 F1402 V1405	T420 F747 F751 R844 E846 F850 V853
BS03	Y01	A	H497 N499 N1357 I1358	H353 N355 N805 I806
BS04	Y01	A	W328 C1611 F1618 F1650 L1653 F1657	W253 C1059 F1066 F1098 L1101 F1105
BS05	Y01	A	R1182 F1189	R641 F648
BS06	CA	A	E309 E1372 G1662	E234 E820 G1110
BS07	Y01	A	N294 M1496 M1497 Y1499	N219 M944 M945 Y947

Gene Ontology

Molecular Function

• GO:0005216 monoatomic ion channel activity
• GO:0005245 voltage-gated calcium channel activity
• GO:0005262 calcium channel activity
• GO:0005509 calcium ion binding
• GO:0008331 high voltage-gated calcium channel activity
• GO:0022843 voltage-gated monoatomic cation channel activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006811 monoatomic ion transport
• GO:0006816 calcium ion transport
• GO:0007268 chemical synaptic transmission
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport
• GO:0098703 calcium ion import across plasma membrane

Cellular Component

• GO:0005886 plasma membrane
• GO:0005891 voltage-gated calcium channel complex
• GO:0016020 membrane
• GO:0034702 monoatomic ion channel complex
• GO:0043025 neuronal cell body
• GO:0045202 synapse

External links

• PDB: RCSB:7xlq, PDBe:7xlq, PDBj:7xlq
• PDBsum: 7xlq
• PubMed: 36720859
• UniProt: Q15878|CAC1E_HUMAN Voltage-dependent R-type calcium channel subunit alpha-1E (Gene Name=CACNA1E)