Structure of PDB 7xlf Chain A

Receptor sequence
>7xlfA (length=282) Species: 627192 (Sphingobium sp. SYK-6) [Search protein sequence]
DKAALSRLFTDYSLEITPKDVEALENAAHMIPPGTLISVTFLPGAEYEDR
ARAAKRIQELGFRPVPHLSARRLIDEADLRTYLDMLKGVIDLKHVFVIAG
DPNEPLGIYEDALALIDSGILKEYGIEHCGISGYPEGHPDITDEKLAKAM
HDKVASLKRQGIDYSIMTQFGFDAEPVLEWLKQIRSEGIDGPVRIGLAGP
ASIKTLLRFAARCGVGTSAKVVKKYGLSITSLIGSAGPDPVIEDLTPVLG
PEHGQVHLHFYPFGGLVKTNEWIVNFKGKQGI
3D structure
PDB7xlf Crystal structural of methylenetetrahydrofolate reductase from Sphingobium sp. SYK-6
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.5.1.54: methylenetetrahydrofolate reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A F47 L48 H73 R77 R78 F102 I104 A105 G106 D107 D117 A118 S138 Y140 H144 I147 A155 K159 F41 L42 H67 R71 R72 F96 I98 A99 G100 D101 D111 A112 S132 Y134 H138 I141 A149 K153
BS02 C2F A E21 L48 D107 Q175 F215 C219 Y267 F269 E15 L42 D101 Q169 F209 C213 Y261 F263
Gene Ontology
Molecular Function
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding
GO:0106312 methylenetetrahydrofolate reductase (NADH) activity
Biological Process
GO:0006555 methionine metabolic process
GO:0009086 methionine biosynthetic process
GO:0035999 tetrahydrofolate interconversion
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xlf, PDBe:7xlf, PDBj:7xlf
PDBsum7xlf
PubMed
UniProtG2IQS8|METF_SPHSK 5,10-methylenetetrahydrofolate reductase (Gene Name=metF)

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