Structure of PDB 7xj0 Chain A

Receptor sequence
>7xj0A (length=606) Species: 9606 (Homo sapiens) [Search protein sequence]
RLKKRIFAAVSEGCVEELVELLVELQELCRRRVPDFLMHKLTASDTGKTC
LMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNI
AIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAAC
TNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMY
DMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLR
SLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLT
LEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPRGWLQLLG
RMFVLIWAMCISVKEGIAIFLLSDAWFHFVFFIQAVLVILSVFLYLFAYK
EYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYI
VFLLGFGVALASLIEKCPKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNS
KYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRAR
TILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSF
LNEDPG
3D structure
PDB7xj0 Structural basis of TRPV3 inhibition by an antagonist.
ChainA
Resolution2.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EQK A A556 W559 A560 I583 A411 W414 A415 I438
BS02 6OU A Y594 F633 Y449 F485
BS03 6OU A I652 L655 I504 L507
BS04 6OU A W433 K438 F445 L563 Y565 T566 F569 W312 K317 F324 L418 Y420 T421 F424
BS05 EQK A V596 F597 G600 F601 F656 T660 I663 L664 V451 F452 G455 F456 F508 T512 I515 L516
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006811 monoatomic ion transport
GO:0008218 bioluminescence
GO:0009266 response to temperature stimulus
GO:0042636 negative regulation of hair cycle
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
GO:0090280 positive regulation of calcium ion import
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043235 receptor complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xj0, PDBe:7xj0, PDBj:7xj0
PDBsum7xj0
PubMed36302896
UniProtQ8NET8|TRPV3_HUMAN Transient receptor potential cation channel subfamily V member 3 (Gene Name=TRPV3)

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