Structure of PDB 7xis Chain A

Receptor sequence
>7xisA (length=145) Species: 11676 (Human immunodeficiency virus 1) [Search protein sequence]
SMYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTN
QKTELQAIYLALQDSGLEVNIVTDSQYALGIITQWIHNWKKRGWKTPVKN
VDLVNQIIEQLIKKEKVYLAWVPAHKGIGGNEQVDKLVSAGIRKV
3D structure
PDB7xis Computational and Crystallographic Analysis of Binding Structures of Inhibitory Compounds for HIV-1 RNase H Activity.
ChainA
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A D23 E58 D78 D19 E54 D74
BS02 MN A D23 D78 D139 D19 D74 D135
BS03 E58 A D23 A25 A26 N54 E58 D78 D139 S143 I146 R147 D19 A21 A22 N50 E54 D74 D135 S139 I142 R143
BS04 ZN A E72 E119 E68 E115
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:7xis, PDBe:7xis, PDBj:7xis
PDBsum7xis
PubMed36184946
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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