Structure of PDB 7xib Chain A

Receptor sequence
>7xibA (length=815) Species: 9606 (Homo sapiens) [Search protein sequence]
GPTKATTTKLVYQIFDTFFAEQIELEVGDCVSVIPLYLARVTALWEDSSN
GQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQLSYIHSKVKVIYKA
PSENWAMEGGMGKTYFYQLWYDQDYARFESPPKTQPKFCVSCARLAEMRQ
KEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPEAFTFNIKLPV
DEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKKSNGRPNETDI
KIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEY
GEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSLPKLRTLDV
FSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGSTVFTEDCNIL
LKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFK
NSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQC
TFGVLQAGQYGVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVV
VDDKKFVSNITRLSSGPFRTITVRDTMSDLPEVRNGASALEISYNGEPQS
WFQRQLRGAQYQPILRDHICKDMSALVAARMRHIPLAPGSDWRDLPNIEV
RLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKACDPAARQFNT
LIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQ
HRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKL
CMLAKARESASAKIK
3D structure
PDB7xib Structural basis for activation of DNMT1.
ChainA
Resolution2.23 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003886 DNA (cytosine-5-)-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006346 DNA methylation-dependent heterochromatin formation
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7xib, PDBe:7xib, PDBj:7xib
PDBsum7xib
PubMed36414620
UniProtP26358|DNMT1_HUMAN DNA (cytosine-5)-methyltransferase 1 (Gene Name=DNMT1)

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