Structure of PDB 7xht Chain A

Receptor sequence

>7xhtA (length=395) Species: 256318 (metagenome) [Search protein sequence]

AVVYVISKSGKPLMPTTRCGHVRILLKEGKARVVERKPFTIQLTYESAEE
TQPLVLGIDPGRTNIGMSVVTESGESVFNAQIETRNKDVPKLMKDRKQYR
MAHRRLKRRCKRRRRAKAAGTAFEEGEKQRLLPGCFKPITCKSIRNKEAR
FNNRKRPVGWLTPTANHLLVTHLNVVKKVQKILPVAKVVLELNRFSLSVL
NQIIPYLADQLADMFPGNFCVTSGQDTYLFREEHGIPKDHYLDAYCIACS
ALTDAKKVSSPKGRPYMVHQFRRHDRQACHKANLNRSYYMGGKLVATNRH
KAMDQKTDSLEEYRAAHSAADVSKLTVKHPSAQYKDMSRIMPGSILVSGE
GKLFTLSRSEGRNKGQVNYFVSTEGIKYWARKCQYLRNNGGLQIY

3D structure

PDB

7xht Structure of the IscB-omega RNA ribonucleoprotein complex, the likely ancestor of CRISPR-Cas9.

Chain

Resolution

2.55 Å

3D
structure

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Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	rna	A	V7 L15 M16 T18 R20 C21 G22 H23 R25 I26 K29 V35 V36 E37 R38 F41 Y47 A50 E52 Q54 R87 M95 R98 Y101 R102 H105 R106 R107 L108 R110 R111 K113 R114 R115 R116C R117 A118 A121 T123 F125 R132 P135 T142 K144 I146 R147 N148 K149 E150 A151 R152 N154 N155 R156 K157 R158 W162 T164 P165 T166 H169 N176 S298 R372 R373 H374 R376 Q377 A378 C379 R386 Y388 N398 R399 H400 K401 A402 M403 L410 R414 A419 V422 S423 K424 L425 H429 Y434 M437 Q484 R487 N488	V5 L13 M14 T16 R18 C19 G20 H21 R23 I24 K27 V33 V34 E35 R36 F39 Y45 A48 E50 Q52 R85 M93 R96 Y99 R100 H103 R104 R105 L106 R108 R109 K111 R112 R113 R114 R115 A116 A119 T121 F123 R130 P133 T140 K142 I144 R145 N146 K147 E148 A149 R150 N152 N153 R154 K155 R156 W160 T162 P163 T164 H167 N174 S198 R272 R273 H274 R276 Q277 A278 C279 R286 Y288 N298 R299 H300 K301 A302 M303 L310 R314 A319 V322 S323 K324 L325 H329 Y334 M337 Q384 R387 N388
BS02	dna	A	C137 F138 K139 I141 F153 R158 G161 W162 F197 Q302 Y306 K381 A382 M403 Y469 W479	C135 F136 K137 I139 F151 R156 G159 W160 F195 Q202 Y206 K281 A282 M303 Y369 W379
BS03	dna	A	H380 Q433 K435 R439 R458 S459 G461 R462	H280 Q333 K335 R339 R358 S359 G361 R362
BS04	MG	A	D61 E193	D59 E191

External links

PDB	RCSB:7xht, PDBe:7xht, PDBj:7xht
PDBsum	7xht
PubMed	36344504

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