Structure of PDB 7xha Chain A

Receptor sequence

>7xhaA (length=765) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

RTLNRYEKIANDIDAIRGDYENLSDDALKHKTIEFKERLEKGATTDDLLV
EAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKTGEGKTLTSTLP
VYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMSKDE
KREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSIL
IDEARTPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTE
EGMTKAEKAFGIDNLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQV
VIVDSFTGRLMKGRRYSEGLHQAIEAKEGLEIQNESMTLATITFQNYFRM
YEKLAGMTGTAKTEEEEFRNIYNMQVVTIPTNRPVVRDDRPDLIYRTMEG
KFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLKNKGIPHQVLNAKN
HEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVVGTERH
ESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGM
DDSTPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQ
RFEVIDSENLREIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINT
TYLDEGALEKSDIFGKEPDEMLELIMDRIITKYNEKEEQFGKEQMREFEK
VIVLRAVDSKWMDHIDAMDQLRQGIHLRAYAQTNPLREYQMEGFAMFEHM
IESIEDEVAKFVMKA

3D structure

• PDB: 7xha Structural basis of SecA-mediated protein translocation.
• Chain: A
• Resolution: 3.35 Å

Enzymatic activity

• Enzyme Commision number: 7.4.2.8: protein-secreting ATPase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	BEF	A	T102 K106	T89 K93
BS02	ADP	A	M79 F80 P81 Q85 G105 K106 Q529	M66 F67 P68 Q72 G92 K93 Q516

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0008564 protein-exporting ATPase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006605 protein targeting
• GO:0006886 intracellular protein transport
• GO:0015031 protein transport
• GO:0017038 protein import
• GO:0043952 protein transport by the Sec complex
• GO:0065002 intracellular protein transmembrane transport

Cellular Component

• GO:0005737 cytoplasm
• GO:0005886 plasma membrane
• GO:0016020 membrane
• GO:0031522 cell envelope Sec protein transport complex
• GO:0045121 membrane raft

External links

• PDB: RCSB:7xha, PDBe:7xha, PDBj:7xha
• PDBsum: 7xha
• PubMed: 36598944
• UniProt: P28366|SECA_BACSU Protein translocase subunit SecA (Gene Name=secA)