Structure of PDB 7xg9 Chain A

Receptor sequence
>7xg9A (length=286) Species: 627192 (Sphingobium sp. SYK-6) [Search protein sequence]
TATLDKAALSRLFTDYSLEITPKDVEALENAAHMIPPGTLISVTFLPGAE
YEDRARAAKRIQELGFRPVPHLSARRLIDEADLRTYLDMLKGVIDLKHVF
VIAGDPNEPLGIYEDALALIDSGILKEYGIEHCGISGYPEGHPDITDEKL
AKAMHDKVASLKRQGIDYSIMTQFGFDAEPVLEWLKQIRSEGIDGPVRIG
LAGPASIKTLLRFAARCGVGTSAKVVKKYGLSITSLIGSAGPDPVIEDLT
PVLGPEHGQVHLHFYPFGGLVKTNEWIVNFKGKQGI
3D structure
PDB7xg9 Crystal structural of methylenetetrahydrofolate reductase from Sphingobium sp. SYK-6
ChainA
Resolution1.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 1.5.1.54: methylenetetrahydrofolate reductase (NADH).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A T46 F47 L48 H73 R77 F102 I104 A105 G106 D107 D117 A118 S138 Y140 H144 D146 I147 K151 A155 K159 M173 T44 F45 L46 H71 R75 F100 I102 A103 G104 D105 D115 A116 S136 Y138 H142 D144 I145 K149 A153 K157 M171
Gene Ontology
Molecular Function
GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity
GO:0016491 oxidoreductase activity
GO:0071949 FAD binding
GO:0106312 methylenetetrahydrofolate reductase (NADH) activity
Biological Process
GO:0006555 methionine metabolic process
GO:0009086 methionine biosynthetic process
GO:0035999 tetrahydrofolate interconversion
Cellular Component
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7xg9, PDBe:7xg9, PDBj:7xg9
PDBsum7xg9
PubMed
UniProtG2IQS8|METF_SPHSK 5,10-methylenetetrahydrofolate reductase (Gene Name=metF)

[Back to BioLiP]