Structure of PDB 7xfg Chain A

Receptor sequence
>7xfgA (length=102) Species: 9606 (Homo sapiens) [Search protein sequence]
SGGRATQSPGDSRRLSIQRAIQSLVHAAQCRNANCSLPSCQKMKRVVQHT
KGCKRKTNGGCPICKQLIALAAYHAKHCQENKCPVPFCLNIKQKGSEFPA
GN
3D structure
PDB7xfg Structural Mechanism of BRD4-NUT Fusion Protein in p300-Activated Hyperacetylation
ChainA
ResolutionN/A
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A R13 S16 I17 R19 S39 K42 M43 V46 I63 Q66 A69 L70 Y73 K76 R13 S16 I17 R19 S39 K42 M43 V46 I63 Q66 A69 L70 Y73 K76
BS02 ZN A H49 C53 C61 C64 H49 C53 C61 C64
BS03 ZN A H26 C30 C35 C40 H26 C30 C35 C40
BS04 ZN A H74 C78 C83 C88 H74 C78 C83 C88
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7xfg, PDBe:7xfg, PDBj:7xfg
PDBsum7xfg
PubMed
UniProtQ09472|EP300_HUMAN Histone acetyltransferase p300 (Gene Name=EP300)

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