Structure of PDB 7xd8 Chain A

Receptor sequence

>7xd8A (length=620) Species: 11060 (dengue virus type 2)

ESETPNLDIIGKRIEKIKQEHETSWHYDQDHPYKTWAYHGSYETKQTGSA
SSMVNGVVRLLTKPWDIIPMVTQMAMTDTTPFGQQRVFKEKVDTRTQEPK
EGTKKLMKITAEWLWKELGKKKTPRMCTREEFTRKVRSNAALGAIFTDEN
KWKSAREAVEDSGFWELVDKERNLHLEGKCETCVYNMMGKREKKLGEFGK
AKGSRAIWYMWLGARFLEFEALGFLNEDHWFSRENSLSGVEGEGLHKLGY
ILRDVSKKEGGAMYADDTAGWDTRITLEDLKNEEMVTNHMEGEHKKLAEA
IFKLTYQNKVVRVQRPTPRGTVMDIISRRDQRGSGQVVTYGLNTFTNMEA
QLIRQMEGEGVFKSIQHLTVTEEIAVKNWLVRVGRERLSRMAISGDDCVV
KPLDDRFASALTALNDMGKVRKDIQQWEPSRGWNDWTQVPFCSHHFHELI
MKDGRVLVVPCRNQDELIGRARISQGAGWSLRETACLGKSYAQMWSLMYF
HRRDLRLAANAICSAVPSHWVPTSRTTWSIHATHEWMTTEDMLTVWNRVW
IQENPWMEDKTPVESWEEIPYLGKREDQWCGSLIGLTSRATWAKNIQTAI
NQVRSLIGNEEYTDYMPSMK

3D structure

• PDB: 7xd8 Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases.
• Chain: A
• Resolution: 2.85 Å

Enzymatic activity

• Enzyme Commision number: 3.4.21.91: flavivirin.
  3.6.1.15: nucleoside-triphosphate phosphatase.
  3.6.4.13: RNA helicase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	A	K402 R404 A407 A408 K457 I474 Y476 R482 N493 G511 G602 V604 W803 V812 R815	K135 R137 A140 A141 K190 I207 Y209 R215 N226 G244 G335 V337 W536 V545 R548
BS02	rna	A	Y607 S661 G662 D663 D664 C709 S710 L754 Y758 M761 S791 R792	Y340 S394 G395 D396 D397 C442 S443 L487 Y491 M494 S524 R525
BS03	ZN	A	H712 H714 C728 C847	H445 H447 C461 C580
BS04	ZN	A	E438 H442 C447 C450	E171 H175 C180 C183

Gene Ontology

Molecular Function

• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005524 ATP binding

Biological Process

• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:7xd8, PDBe:7xd8, PDBj:7xd8
• PDBsum: 7xd8
• PubMed: 36577062
• UniProt: Q91H74