Structure of PDB 7xa9 Chain A

Receptor sequence

>7xa9A (length=702) Species: 3702 (Arabidopsis thaliana) [Search protein sequence]

HIESLDYEINENDLFKHDWRSRSKAQVFQYIFLKWTLACLVGLFTGLIAT
LINLAVENIAGYKLLAVGYYIAQDRFWTGLMVFTGANLGLTLVATVLVVY
FAPTAAGPGIPEIKAYLNGIDTPNMFGFTTMMVKIVGSIGAVAAGLDLGK
EGPLVHIGSCIASLLGQGGPDNHRIKWRWLRYFNNDRDRRDLITCGSASG
VCAAFRSPVGGVLFALEEVATWWRSALLWRTFFSTAVVVVVLRAFIEICN
SGKCGLFGSGGLIMFDVSHVEVRYHAADIIPVTLIGVFGGILGSLYNHLL
HKVLRLYNLINQKGKIHKVLLSLGVSLFTSVCLFGLPFLAECKPCDPSID
EICPTNGRSGNFKQFNCPNGYYNDLSTLLLTTNDDAVRNIFSSNTPNEFG
MVSLWIFFGLYCILGLITFGIATPSGLFLPIILMGSAYGRMLGTAMGSYT
NIDQGLYAVLGAASLMAGSMRMTVSLCVIFLELTNNLLLLPITMFVLLIA
KTVGDSFNLSIYEIILHLKGLPFLEANPEPWMRNLTVGELNDAKPPVVTL
NGVEKVANIVDVLRNTTHNAFPVLDTELHGLILRAHLVKVLKKRWFLNEK
RRTEEWEVREKFTPVELAEREDNFDDVAITSSEMQLYVDLHPLTNTTPYT
VVQSMSVAKALVLFRSVGLRHLLVVPKSPVIGILTRQDLRAYNILQAFPH
LD

3D structure

PDB

7xa9 Cryo-EM structure of the plant nitrate transporter AtCLCa reveals characteristics of the anion-binding site and the ATP-binding pocket.

Chain

Resolution

2.84 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	NO3	A	P160 I162 G478 L479 F480 Y564	P108 I110 G426 L427 F428 Y512
BS02	NO3	A	G201 E203 G204 G478 L479 F480 L481	G149 E151 G152 G426 L427 F428 L429
BS03	NO3	A	P160 K571	P108 K519
BS04	ATP	A	H53 E55 S56 K596 V600 H620 N621 A622 F623 R729 H730 I748 T750 D753	H1 E3 S4 K544 V548 H568 N569 A570 F571 R670 H671 I683 T685 D688
BS05	MG	A	H53 E55	H1 E3

Gene Ontology

	Molecular Function
GO:0005247	voltage-gated chloride channel activity
GO:0005254	chloride channel activity
GO:0005515	protein binding
GO:0015112	nitrate transmembrane transporter activity

	Biological Process
GO:0006821	chloride transport
GO:0010167	response to nitrate
GO:0015706	nitrate transmembrane transport
GO:0034220	monoatomic ion transmembrane transport
GO:0055085	transmembrane transport
GO:1902476	chloride transmembrane transport

	Cellular Component
GO:0016020	membrane
GO:0034707	chloride channel complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7xa9, PDBe:7xa9, PDBj:7xa9
PDBsum	7xa9
PubMed	36581207
UniProt	P92941\|CLCA_ARATH Chloride channel protein CLC-a (Gene Name=CLC-A)

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