Structure of PDB 7x6v Chain A

Receptor sequence

>7x6vA (length=1381) Species: 11624 (Lymphocytic choriomeningitis virus (strain Armstrong))

MDEIISELRELCLNYIEQDERLSRQKLNFLGQREPRMVLIEGLKLLSRCI
EIDSADKSGCTHNHDDKSVETILVESGIVCPGLPLIIPDGYKLIDNSLIL
LECFVRSTPASFEKKFIEDTNKLACIREDLAVAGVTLVPIVDGRCDYDNS
FMPEWANFKFRDLLFKLLEYSNQNEKVFEESEYFRLCESLMDSMKILKDA
RSTHNDEIMRMCHEGINPNMSCDDVVFGINSLFSRFRRDLESGKLKRNFQ
KVNPEGLIKEFSELYENLADSDDILTLSREAVESCPLMRFITAETHGTEY
ERLLSMLNKVKSLKLLNTRRRQLLNLDVLCLSSLIKQSCYSSVNDRLVSF
HSTKEEFIRLLRNRKKSKVRASISEFIAKIQKCLLVVGLSFEHYGLSEHL
EQECHIPFTEFENFMKIGAHPIMYYNFQPSTEQLKNIQSLRRLSSVCLAL
TNSMKTSSVCKEVFCQVIKLDSEEYHLLYQKTGESSRCYSIQGPDGHLIS
FYADPKRFFLPIFSDEVLYNMIDIMISWIRSCPDLKDCLTDIEVALRTLL
LLMLTNPTKRNQKQVQSVRYLVMAIVSDFSSTSLMDKLREDLITPAEKVV
YKLLRFLIKTIFGTGEKVLLSAKFKFMLNVSYLCHLITKETPDRLTDQIK
CFEKFFEPKSQFGFFVNPKEAITPEEECVFYEQMKRFTSKEIDCQHTTPG
VNLEAFSLMVSSFNNGTLIFYEYKVSKLVSRLVIGSKGEETMSAALKNLC
FYSEESPTSYTSVGPDSGRLKFALSYKEQVGGNRELYIGDLRTKMFTRLI
EDYFESFSSFFSGSCLNNDKEFENAILSMTINVREGFLNYSMDHSKWGPM
MCPFLFLMFLQNLKLGDDQYVRSGKDHVSTLLTWHMHKLVEVPFPVVNAM
MKSYVKSKLKETTVTERIFRQYFEMGIVPSHISSLIDMGQGILHNASDFY
GLLSERFINYCIGVIFGERPEAYTSSDDQITLFDRRLSDLVVSDPEEVLV
LLEFQSHLSGLLNKFISPKSVAGRFAAEFKSRFYVWGEEVPLLTKFVSAA
LHNVKCKEPHQLCETIDTIADQAIANGVPVSLVNSIQRRTLDLLKYANFP
LDPFLLNTNTDVKDWLDGSRGYRIQRLIEELCPNETKVVRKLVRKLHHKL
KNGEFNEEFFLDLFNRDKKEAILQLGDLLGLEEDLNQLADVNWLNLNEMF
PLRMIPSLIKTLQNKLCISSGFIGLCKTLGSRCVRNKNRENLYIKKLLED
LTTDDHVTRVCNRDGITLYICDKQSHPEAHRDHICLLRPLLWDYICISLS
NSFELGVWVLAEPKVNLNQVIQSVRRLYPKIFEDQLLPIKFLDLCVLIDI
NSESLSLISHVVKWKRDEHYTVLFSDLANSH

3D structure

• PDB: 7x6v Structure basis for allosteric regulation of lymphocytic choriomeningitis virus polymerase function by Z matrix protein.
• Chain: A
• Resolution: 3.6 Å

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.
  3.1.-.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MN	A	D1182 D1322 E1372	D843 D978 E1028

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0005515 protein binding
• GO:0016787 hydrolase activity
• GO:0034062 5'-3' RNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0019079 viral genome replication
• GO:0039689 negative stranded viral RNA replication
• GO:0039694 viral RNA genome replication
• GO:0039696 RNA-templated viral transcription
• GO:0075526 cap snatching

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0044423 virion component

External links

• PDB: RCSB:7x6v, PDBe:7x6v, PDBj:7x6v
• PDBsum: 7x6v
• PubMed: 37038286
• UniProt: P14240|L_LYCVA RNA-directed RNA polymerase L (Gene Name=L)